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Updated: Sep 29, 2025

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
Venoarterial extracorporeal membrane oxygenation for septic cardiomyopathy caused by Pasteurella multocida infection:
Ai Nagai1, Takeshi Adachi2, Yoshiyuki Nishizawa1
1Department of Anesthesiology, Kitasato University, School of Medicine, 1-15-1 Kitasato Minami-ku, Sagamihara City, Kanagawa, 252-0375, Japan.
Abstract:
Pasteurella is a gram-negative coccobacillus that is commonly transmitted through cat and dog bites and causes various diseases in humans. In the present case, kissing an animal caused Pasteurella multocida infection, leading to sepsis and cardiogenic shock. We used venoarterial extracorporeal membrane oxygenation (VA-ECMO) to support the cardiovascular system until recovery. A 62-year-old man with no relevant history was referred to our hospital with a 1-day history of sore throat and fever. He was diagnosed with cervical cellulitis and later developed septic shock, which necessitated catecholamine administration and intubation. It was subsequently revealed that the patient had Pasteurella multocida bacteremia and kept a pet dog at home. In addition to sepsis, the patient experienced refractory cardiogenic shock and was unresponsive to medical treatment; therefore, VA-ECMO was initiated. After its introduction, the patient's hemodynamic status improved, and he was weaned from extracorporeal circulation after 6 days. He was discharged home and resumed his former life 50 days later. Pasteurella multocida infection can cause sepsis followed by severe cardiac dysfunction in healthy adults. Therefore, VA-ECMO may be a useful treatment option in patients with sepsis-induced myocardial dysfunction and refractory cardiogenic shock.
Insights
Kissing a pet dog led to a severe Pasteurella multocida infection, causing sepsis and cardiogenic shock. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) successfully supported the patient until recovery, highlighting its potential in critical cases.
Area of Science:
- Infectious Diseases
- Cardiology
- Critical Care Medicine
Background:
- Pasteurella multocida, a gram-negative coccobacillus, is typically transmitted via animal bites.
- Infections can lead to severe systemic complications, including sepsis and cardiovascular compromise.
Observation:
- A 62-year-old man developed Pasteurella multocida sepsis and refractory cardiogenic shock after kissing his pet dog.
- Initial treatment for cervical cellulitis and septic shock was insufficient.
Findings:
- The patient required venoarterial extracorporeal membrane oxygenation (VA-ECMO) for cardiovascular support.
- Hemodynamic status improved significantly after VA-ECMO initiation, with successful weaning after 6 days.
Implications:
- Pasteurella multocida infections can cause severe sepsis-induced myocardial dysfunction even in healthy adults.
- VA-ECMO is a viable therapeutic option for managing refractory cardiogenic shock in sepsis.
- Early recognition and aggressive management are crucial for favorable outcomes in severe Pasteurella infections.

