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Liver failure caused by intravenous amiodarone and effective intervention measures: A case report
Zhouqian Jiang1, Chengfei Zhao2,3, Xiaoyun Li1
1Department of Pharmacy, Hezhou People's Hospital, Hezhou, China.
What Is Known And Objective:
We present a case of intravenous amiodarone-induced liver injury, pharmacy monitoring and its therapy.
Case Summary:
A 76-year-old male patient developed acute liver injury 24 h after starting intravenous amiodarone. His liver enzymes improved after discontinuing amiodarone and anti-inflammatory liver therapy, which used reduced glutathione, magnesium isoglycyrrhizinate and ademetionine1,4-butanedisulfonate for injection.
What Is New And Conclusion:
Amiodarone is a highly effective antiarrhythmic agent for the treatment and prevention of atrial and ventricular arrhythmias. Acute liver damage after intravenous amiodarone is rare but potentially harmful. Amiodarone loading should be adapted to the necessity of an immediate effect of the drug, and liver function should be monitored closely in critically ill patients. Timely stopped suspected drug and anti-inflammatory liver therapy may reduce the occurrence of drug-induced diseases.
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