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Compact Surface Plasmon Resonance IgG Sensor Based on H-Shaped Optical Fiber
Yijian Huang1,2,3, Ying Wang1,3, Gaixia Xu2
1Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Biosensors
|March 24, 2022
Summary
Researchers developed a novel H-shaped optical fiber surface plasmon resonance sensor. This compact, low-cost sensor enables efficient biomarker detection, achieving a minimum human IgG concentration detection limit of 3.4 μg/mL.
Area of Science:
- Photonics and Sensor Technology
- Biomedical Engineering
- Materials Science
Background:
- Surface plasmon resonance (SPR) sensors are crucial for detecting biomolecules.
- Traditional fabrication methods for SPR fiber sensors can be complex and costly.
- There is a need for compact, easily fabricated, and cost-effective SPR sensor platforms.
Purpose of the Study:
- To propose and demonstrate a novel compact SPR sensor utilizing an H-shaped optical fiber.
- To investigate the fabrication process and optimize sensor performance.
- To evaluate the sensor's capability for specific biomarker detection.
Main Methods:
- Fabrication of H-shaped optical fibers via controlled hydrofluoric acid corrosion of polarization-maintaining fibers.
- Coating the H-shaped fiber with a metal film to excite surface plasmon resonance.
- Investigating the influence of fiber remaining thickness, coating thickness, and fiber length on spectral properties.
- Testing the sensor's performance for human immunoglobulin G (IgG) detection.
Main Results:
- Successfully fabricated compact H-shaped optical fibers with high surface quality and short lengths (hundreds of microns).
- Demonstrated the excitation of SPR effect by optimizing metal film thickness.
- Analyzed the impact of key fabrication parameters on sensor performance.
- Achieved a minimum detectable concentration of 3.4 μg/mL for human IgG.
Conclusions:
- The H-shaped optical fiber SPR sensor offers advantages in easy fabrication, good consistency, and low cost.
- The developed sensor is suitable for specific biomarker detection.
- This technology shows promise for point-of-care diagnostics and sensitive biological analysis.
