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Metabolomic Studies in Inner Ear Pathologies.

Luc Boullaud^1,2, Hélène Blasco^2,3,4, Thuy-Trân Trinh^1,3

¹ENT Department and Cervico-Facial Surgery, University Center Hospital of Tours, 2 Boulevard Tonnellé, 37044 Tours, France.

|March 24, 2022

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Metabolomics, the study of metabolites, offers new insights into sensorineural hearing loss. This review suggests metabolomic approaches could lead to better diagnostic tests and personalized treatments for hearing conditions.

Area of Science:

Otolaryngology
Genetics
Biochemistry

Background:

Sensorineural hearing loss (SNHL) is a prevalent sensory deficit with diverse congenital and acquired causes.
While etiologies are known for some SNHL types, mechanisms of progressive post-lingual SNHL remain unclear.
Metabolomics analyzes all metabolites in a sample to reflect physiological status.

Purpose of the Study:

To review the existing literature on the application of metabolomics in understanding hearing loss.
To explore the potential of metabolomics in diagnosing and treating SNHL.

Main Methods:

Systematic literature review of studies utilizing metabolomics for hearing loss research.
Analysis of identified metabolites and their association with SNHL pathologies.

Keywords:

metabolomic perilymph sensorineural hearing loss

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Main Results:

Metabolomic studies reveal potential biomarkers for SNHL.
The technique shows promise in elucidating pathological mechanisms in progressive hearing loss.
Identified metabolic pathways may be targets for therapeutic intervention.

Conclusions:

Metabolomics is a valuable emerging tool for SNHL research.
Metabolomic findings suggest potential for developing objective diagnostic tests.
Personalized treatment strategies for SNHL may be advanced through metabolomics.