Related Experiment Video
Updated: Sep 29, 2025
07:45
Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
3.7K
Relationship between Urinary Calcium Excretion and Lower Urinary Tract Symptoms
Tomohiro Matsuo1, Hidenori Ito1, Kensuke Mitsunari1
1Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Metabolites
|March 24, 2022
Summary
High urinary calcium excretion (hypercalciuria) is linked to overactive bladder (OAB), nocturia, and nocturnal polyuria. This study identifies hypercalciuria as a significant risk factor for these lower urinary tract symptoms (LUTS) in adults.
Area of Science:
- Urology
- Nephrology
- Endocrinology
Background:
- Lower urinary tract symptoms (LUTS), including overactive bladder (OAB) and nocturia, lack convenient prevalence markers.
- Hypercalciuria, indicated by high urinary calcium excretion, is associated with lifestyle-related diseases like hypertension, which may contribute to LUTS.
- Existing research has limited detailed studies on the connection between urinary calcium excretion and LUTS prevalence.
Purpose of the Study:
- To investigate the relationship between urinary calcium excretion levels and the occurrence of OAB, nocturia, and nocturnal polyuria in adults.
- To determine if hypercalciuria is a significant risk factor for developing OAB, nocturia, and nocturnal polyuria.
- To explore the association between the severity of LUTS and urinary calcium excretion.
Main Methods:
- Adult participants were assessed for urinary calcium excretion levels.
- Prevalence and severity of OAB, nocturia, and nocturnal polyuria were evaluated in the study cohort.
- Statistical analyses were performed to determine the correlation between urinary calcium excretion and LUTS parameters.
Main Results:
- Patients exhibiting hypercalciuria demonstrated a higher frequency of experiencing OAB, nocturia, and nocturnal polyuria.
- A significant association was found between the severity of LUTS and urinary calcium excretion levels.
- Hypercalciuria was identified as a notable risk factor contributing to the development of OAB, nocturia, and nocturnal polyuria.
Conclusions:
- Hypercalciuria is significantly associated with the prevalence and severity of overactive bladder, nocturia, and nocturnal polyuria.
- Elevated urinary calcium excretion emerges as a critical risk factor for these common lower urinary tract symptoms.
- This study highlights the potential of monitoring urinary calcium levels as a marker for LUTS risk assessment.
Related Concept Videos
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
56
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
56
01:28Urinary Tract Calculi I: Introduction
63
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
63
01:30Urinary Tract Calculi III: Medical Management
43
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
43
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
46
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
46
01:28Urinary Tract Calculi V: Nursing Management
56
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
56
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
57
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
57