Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Erythropoiesis

Erythropoiesis

Red blood cells (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving the stability of cultured red blood cells during storage.

Vox sanguinis·2025

Same author

Red cell special interest group 2024.

Transfusion medicine (Oxford, England)·2025

Same author

Vesiculation in irradiated and cation-leaky-stored red blood cells.

Transfusion·2023

Same author

The compound effect of irradiation and familial pseudohyperkalemia on potassium leak from red blood cells.

Transfusion·2022

Same author

Reticulocyte Maturation and Variant Red Blood Cells.

Frontiers in physiology·2022

Same author

Red cell membrane proteins.

HemaSphere·2022

Same journal

Optimized Digestion Conditions for Membrane Protein Footprinting and Mass Spectrometry Analysis.

Membranes·2026

Same journal

GCMembrane-LLM: An Evidence-Grounded Domain-Specific Large Language Model for Structure-Performance Reasoning in Graphene and Carbon Nanotube Separation Membranes.

Membranes·2026

Same journal

The Structural Evolution of Recrystallized Asymmetric SiC Membranes for High-Performance Oily Wastewater Treatment.

Membranes·2026

Same journal

Full-Scale Microfiltration for Drinking Water: A Long-Term Performance Analysis.

Membranes·2026

Same journal

Transport Coherence Loss in Heterogeneous Forward Osmosis Membranes: A Hierarchical Diagnostic Framework.

Membranes·2026

Same journal

Coupled Transport, Plasticization, and Retention Mechanisms in Phosphoric Acid-Doped PBI Membranes.

Membranes·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 29, 2025

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

Reticulocyte Maturation.

Christian J Stevens-Hernandez^1,2, Lesley J Bruce¹

¹Bristol Institute for Transfusion Sciences, National Health Service (NHS) Blood and Transplant, Bristol BS34 7QH, UK.

|March 24, 2022

Summary

This summary is machine-generated.

Reticulocyte maturation into red blood cells involves membrane and cytoskeleton changes. This review explores mechanisms, including organelle removal, and incomplete maturation in red cell variants.

Keywords:

incomplete reticulocyte maturation red cell membrane proteins red cell variants reticulocyte maturation

More Related Videos

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry

Published on: June 6, 2014

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

Related Experiment Videos

Last Updated: Sep 29, 2025

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry

Identification of a Murine Erythroblast Subpopulation Enriched in Enucleating Events by Multi-spectral Imaging Flow Cytometry

Published on: June 6, 2014

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

Area of Science:

Hematology
Cell Biology
Membrane Biology

Background:

Reticulocyte maturation into erythrocytes requires significant cellular changes.
Mechanisms include membrane protein alterations, cytoskeleton rearrangement, and organelle elimination.
Processes like autophagy and exosome release contribute to reticulocyte maturation.

Purpose of the Study:

To review the mechanisms of reticulocyte maturation.
To compare mature red blood cell membranes with reticulocyte membranes.
To focus on incomplete reticulocyte maturation in red cell variants.

Main Methods:

Literature review comparing reticulocyte and mature red blood cell membrane structures.
Discussion of proposed reticulocyte maturation mechanisms.
Analysis of red cell variants with membrane defects or cation leak disorders.

Main Results:

Reticulocyte maturation involves reducing plasma membrane size and eliminating organelles.
Lysosomal degradation, exosome release, and autophagy are key processes.
Red cell variants with defects provide insights into maturation pathways.

Conclusions:

Reticulocyte maturation is a complex process involving multiple cellular mechanisms.
Incomplete maturation, observed in certain red cell variants, highlights the intricacies of this process.
Further research is needed to fully elucidate the mechanisms of reticulocyte maturation.