Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transgenic Organisms

Transgenic Organisms

Bioreactor Controls-III

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-input CSF cfDNA shallow whole-genome sequencing for CNV-based diagnosis and monitoring of leptomeningeal metastasis in lung cancer.

Acta neuropathologica communications·2026

Same author

Development of Glycosylated and Dimeric FAP-Targeted Radiotracers for Preclinical Evaluation in FAP-Positive Glioblastoma Models.

Journal of medicinal chemistry·2026

Same author

Upcycling Commodity Polymers into Semiconductors by Sequential Grafting of Aromatic Units through Regioselective Iodination and Living Suzuki-Miyaura Catalyst-Transfer Polymerization.

Journal of the American Chemical Society·2026

Same author

Antitumor efficacy and safety of locoregional [<sup>177</sup>Lu]Lu-RM26 radionuclide therapy in glioblastoma.

European journal of nuclear medicine and molecular imaging·2026

Same author

Corrigendum to "Oleanolic acid 28-O-β-D-glucopyranoside alleviates TNBS-induced ulcerative colitis in rat by regulating Nrf2/x-CT/GPX4-mediated ferroptosis" [Journal of Ethnopharmacology 353 (2025) 120369].

Journal of ethnopharmacology·2026

Same author

Tribranched Multiblock Copolymers Mimicking the Molecular Claw Design in N-Type Conjugated Polymers for High-Yield Semiconducting Carbon Nanotube Sorting and Phototransistor Memory Applications.

ACS applied materials & interfaces·2026

Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026

Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026

Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026

Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026

Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026

Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

Published on: January 21, 2016

Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics.

Yuanwen Jiang¹, Zhitao Zhang¹, Yi-Xuan Wang^1,2

¹Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

Science (New York, N.Y.)

|March 24, 2022

Summary

This summary is machine-generated.

Researchers developed robust, stretchable electronic devices using molecular engineering. These devices offer high conductivity and patternability for seamless integration with the human body, enabling precise biological signal collection and control.

More Related Videos

A Simple and Scalable Fabrication Method for Organic Electronic Devices on Textiles

A Simple and Scalable Fabrication Method for Organic Electronic Devices on Textiles

Published on: March 13, 2017

Scalable Solution-processed Fabrication Strategy for High-performance, Flexible, Transparent Electrodes with Embedded Metal Mesh

Scalable Solution-processed Fabrication Strategy for High-performance, Flexible, Transparent Electrodes with Embedded Metal Mesh

Published on: June 23, 2017

Related Experiment Videos

Last Updated: May 6, 2026

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

Published on: January 21, 2016

A Simple and Scalable Fabrication Method for Organic Electronic Devices on Textiles

A Simple and Scalable Fabrication Method for Organic Electronic Devices on Textiles

Published on: March 13, 2017

Scalable Solution-processed Fabrication Strategy for High-performance, Flexible, Transparent Electrodes with Embedded Metal Mesh

Scalable Solution-processed Fabrication Strategy for High-performance, Flexible, Transparent Electrodes with Embedded Metal Mesh

Published on: June 23, 2017

Area of Science:

Bioelectronic devices
Materials science
Organic electronics

Background:

Stretchable bioelectronic devices are crucial for human integration.
Combining mechanical robustness with electrical conductivity in these devices is challenging, especially at small scales.
Existing materials often compromise performance for flexibility or conductivity.

Purpose of the Study:

To develop intrinsically stretchable bioelectronic devices with high mechanical robustness and electrical conductivity.
To achieve fine-scale patterning for cellular-level integration.
To demonstrate the utility of these devices in biological applications.

Main Methods:

Molecular engineering using a topological supramolecular network.
Direct photopatterning down to the cellular scale.
Fabrication of intrinsically stretchable and conductive organic materials.

Main Results:

Achieved simultaneous high conductivity and crack-onset strain in a physiological environment.
Demonstrated direct photopatternability at the cellular scale.
Successfully collected stable electromyography signals and performed localized neuromodulation with single-nucleus precision.

Conclusions:

The developed molecular engineering strategy effectively decouples competing material properties.
The new materials enable robust, highly conductive, and precisely patterned bioelectronic devices.
These advancements pave the way for sophisticated, integrated bioelectronic systems for medical and research applications.