Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ABH antibodies causing platelet transfusion refractoriness.

A Brand, K Sintnicolaas, F H Claas

    Transfusion
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Value of Routine Pelvic Examination in the Follow-Up of Patients Receiving Adjuvant Radiation Therapy for Endometrial Cancer: An Australian Tertiary-Centre Experience.

    Journal of medical imaging and radiation oncology·2025
    Same author

    Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells.

    Journal of dental research·2024
    Same author

    Medical graphics to improve patient understanding and anxiety in elderly and cognitively impaired patients scheduled for transcatheter aortic valve implantation (TAVI).

    Clinical research in cardiology : official journal of the German Cardiac Society·2023
    Same author

    Informed Consent before coronary angiography and percutaneous coronary intervention from the patient's perspective: A picture is worth a thousand words.

    International journal of cardiology. Heart & vasculature·2022
    Same author

    Review of indications for immunoglobulin (IG) use: Narrowing the gap between supply and demand.

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2020
    Same author

    A nurse- and peer-led psycho-educational intervention to support women with gynaecological cancers receiving curative radiotherapy: The PeNTAGOn randomised controlled trial - ANZGOG 1102.

    Gynecologic oncology·2020

    High-titered ABH antibodies in alloimmunized patients cause complete destruction of incompatible platelets, leading to transfusion failure. Matching ABO blood type is crucial for successful HLA-identical platelet transfusions.

    Area of Science:

    • Immunology
    • Transfusion Medicine
    • Hematology

    Background:

    • Alloimmunized patients often develop antibodies against human leukocyte antigen (HLA) andABO (H) blood group system (ABH) antigens.
    • Platelet transfusion refractoriness can occur in these patients, complicating management.

    Observation:

    • Two alloimmunized patients with high-titered anti-ABH antibodies experienced transfusion failures with ABH-mismatched, HLA-identical platelet transfusions.
    • ABH-matched, HLA-identical platelets resulted in sufficient platelet increments in these patients.
    • Anti-A and anti-B antibodies were detected on transfused platelets using immunofluorescence assays.

    Findings:

    • The study demonstrated that ABH antibodies bind to platelets.
    • These platelet-bound antibodies could be removed by absorption with ABH-typed red blood cells and platelets.

    Related Experiment Videos

  • Unlike previous reports suggesting partial destruction, almost all ABH-incompatible platelets were destroyed post-infusion.

    • Implications:

    • This highlights the critical role of ABO compatibility in platelet transfusions for alloimmunized patients.
    • Complete destruction of ABH-incompatible platelets underscores the need for careful pre-transfusion compatibility testing.
    • Clinical practice should prioritize ABO-matched platelet transfusions to ensure efficacy in patients with high-titered ABH antibodies.