Exogenous prostaglandins and gastric secretion in the cat

1. In the conscious gastric fistula cate PGE2 was shown to produce dose-related inhibition of gastric acid and pepsin secreted in response to pentagastrin, histamine and insulin. 2. PGF2alpha had little effect on pentagastrin-stimulated gastric acid and pepsin secretion. 3PGF2 delayed the tachyphylaxis of gastric acid stimulated by pentagastrin and histamine, but not that stimulated by insulin. 4. Although not delaying tachyphylaxis of insulin stimulated acid, PGE2 delayed tachyphylaxis of insulin stimulated pepsin.