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Percutaneous Egression: What Do We Know?

Qisi Sun1,2, Caitlin G Purvis3, Sahir N Iqbal3

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.

Skin Pharmacology and Physiology
|March 24, 2022
PubMed
Summary
This summary is machine-generated.

Drugs can enter skin layers from the bloodstream through various percutaneous egression mechanisms, including sweat and sebum transport, depending on their properties. Understanding these pathways is crucial for developing effective drug delivery systems.

Keywords:
AdministrationDiffusionDrugPercutaneous egressionWick effect

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Area of Science:

  • Dermatology
  • Pharmacology
  • Drug Delivery

Background:

  • Understanding drug movement from blood to skin is vital for effective medication development.
  • Percutaneous egression mechanisms influence drug delivery routes and efficacy.

Purpose of the Study:

  • To review and synthesize existing literature on how drugs exit the bloodstream into skin compartments.
  • To identify and categorize the various mechanisms of percutaneous drug egression.

Main Methods:

  • A general literature review was conducted.
  • Existing studies on percutaneous egression were analyzed.

Main Results:

  • The stratum corneum (SC) serves as a compartment for systemically delivered drugs.
  • Multiple percutaneous egression mechanisms exist, influenced by drug physiochemical properties.
  • Mechanisms include desquamation, sebum secretion, sweat transport, and passive diffusion.

Conclusions:

  • Hydrophilic drugs utilize sweat transport, while lipophilic drugs use sebum secretion to reach the SC.
  • Drugs spread laterally on the skin surface before re-penetrating, mimicking topical administration.
  • Further research is needed to fully elucidate percutaneous egression pathways and drug action sites for improved drug development.