Related Experiment Video
Updated: Sep 29, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Redox-Related Proteins in Melanoma Progression
Larissa A C Carvalho1, Rodrigo G Queijo1, Alexandre L B Baccaro2
1Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, 580, São Paulo 05508-00, SP, Brazil.
Redox proteins are key in melanoma progression and resistance. Targeting these proteins, like NOS2 and SOD1, may offer new therapeutic strategies for this aggressive skin cancer.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Melanoma is an aggressive skin cancer with refractory minimal residual disease.
- Reactive oxygen and nitrogen species (ROS/RNS) play a dual role in melanoma, influencing initiation to metastasis.
- Redox proteins are crucial in modulating melanoma by controlling ROS/RNS levels.
Purpose of the Study:
- To analyze the expression of redox-generating and detoxifying proteins in melanoma.
- To investigate the correlation between protein expression, genetic alterations, and patient survival.
- To identify potential therapeutic targets by understanding redox homeostasis modulation.
Main Methods:
- Analysis of a public cohort of melanoma patients.
- Assessment of differential expression of redox-related protein isoforms.
- Examination of genetic alterations and their impact on patient survival.
Main Results:
- 66% of isoforms showed differential expression during melanoma progression (e.g., increased NOS2, SOD1; decreased CAT, GPX3).
- Disease stage influenced expression levels for some isoforms (e.g., PRX1, PRX5, PRX6).
- All analyzed isoforms had genetic alterations, mostly increasing mRNA expression (78%); TRX1 alterations were notable (34% decreased mRNA).
Conclusions:
- Redox-sensitive proteins are significantly altered in melanoma and impact patient survival.
- Specific isoforms like PRX3, PRX5, TR2, GR, and NOX4 are linked to survival outcomes.
- Targeting redox homeostasis presents a promising avenue for novel melanoma therapies.
More Related Videos
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
10:24Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
Published on: June 7, 2018
Related Concept Videos
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Redox Reactions
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Redox Equilibria: Overview