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Updated: Sep 29, 2025
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Modulation of Cellular Redox Parameters for Improving Therapeutic Responses in Multiple Myeloma
Alessandro Allegra1, Claudia Petrarca2,3, Mario Di Gioacchino2,3
1Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Abstract:
Raised oxidative stress and abnormal redox status are typical features of multiple myeloma cells, and the identification of the intimate mechanisms that regulate the relationships between neoplastic cells and redox homeostasis may reveal possible new anti-myeloma therapeutic targets to increase the effectiveness of anti-myeloma drugs synergistically or to eradicate drug-resistant clones while reducing toxicity toward normal cells. An alteration of the oxidative state is not only responsible for the onset of multiple myeloma and its progression, but it also appears essential for the therapeutic response and for developing any chemoresistance. Our review aimed to evaluate the literature's current data on the effects of oxidative stress on the response to drugs generally employed in the therapy of multiple myeloma, such as proteasome inhibitors, immunomodulators, and autologous transplantation. In the second part of the review, we analyzed the possibility of using other substances, often of natural origin, to modulate the oxidative stress to interfere with the progression of myelomatous disease.
Insights
Oxidative stress impacts multiple myeloma (MM) progression and drug resistance. Modulating redox balance, potentially with natural compounds, offers new therapeutic strategies against MM.
Area of Science:
- Oncology
- Biochemistry
Background:
- Multiple myeloma (MM) cells exhibit elevated oxidative stress and altered redox status.
- Oxidative state dysregulation is implicated in MM onset, progression, and chemoresistance.
Purpose of the Study:
- To review the effects of oxidative stress on MM response to current therapies.
- To explore natural compounds for modulating oxidative stress in MM treatment.
Main Methods:
- Literature review of studies on oxidative stress in multiple myeloma.
- Analysis of therapeutic responses to proteasome inhibitors, immunomodulators, and autologous transplantation in relation to redox status.
- Exploration of natural substances for redox modulation in MM.
Main Results:
- Oxidative stress significantly influences MM cell behavior and response to standard therapies.
- Chemoresistance in MM is closely linked to alterations in the cellular oxidative state.
- Natural compounds show potential for modulating redox homeostasis and impacting MM progression.
Conclusions:
- Targeting oxidative stress presents a promising strategy for enhancing MM therapy.
- Synergistic effects with existing drugs and overcoming drug resistance are potential benefits.
- Natural products offer a viable avenue for developing novel redox-modulating anti-myeloma agents.
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