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Updated: Sep 29, 2025
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Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence
Daniele Lettieri-Barbato1,2, Katia Aquilano1, Carolina Punziano3
1Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Antioxidants (Basel, Switzerland)
|March 25, 2022
Summary
Cell senescence plays key roles in development and aging. Non-coding RNAs are vital in regulating cellular responses to oxidative stress, influencing senescence pathways.
Area of Science:
- Cellular Biology
- Molecular Biology
- Aging Research
Background:
- Cell senescence is crucial for tissue development, homeostasis, and tumor suppression.
- Senescence is increasingly linked to organismal aging and age-related diseases.
- Oxidative stress, caused by an imbalance in reactive oxygen and nitrogen species (ROS/RNS), is a major driver of cellular damage and senescence.
Purpose of the Study:
- To review the link between ROS/RNS-induced cell senescence.
- To summarize the role of non-coding RNAs in the senescence program.
Main Methods:
- Literature review of recent data.
- Analysis of the interplay between oxidative stress, senescence, and non-coding RNAs.
Main Results:
- Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, are critical mediators of cellular processes.
- These non-coding RNAs play significant roles in responding to oxidative stress and regulating senescence.
Conclusions:
- Non-coding RNAs are key regulators in the cellular response to oxidative stress-induced senescence.
- Understanding these pathways offers insights into aging and age-related diseases.
Keywords:
agingcell senescencecircular RNAslong non-coding RNAsmicroRNAsnon-coding RNAsoxidative stressredox homeostasisMore Related Videos
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