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Microbiota and Pain: Save Your Gut Feeling

Chiara Morreale1, Ilia Bresesti1, Annalisa Bosi2

  • 1Department of Woman and Child, ASST-Settelaghi, University of Insubria, 21100 Varese, Italy.

Cells
|March 25, 2022
PubMed

Insights

The gut-brain axis influences pain perception. Probiotics show potential for managing pain by modulating the gut microbiota, offering new therapeutic avenues for pain relief.

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • The gut-brain axis, a bidirectional communication network, plays a crucial role in health and disease.
  • Emerging evidence links microbiota dysregulation to pain conditions like visceral hypersensitivity and inflammatory pain.
  • The gut microbiota's composition is influenced by stress, impacting pain perception.

Purpose of the Study:

  • To review the mechanisms of pain processing and regulation.
  • To highlight the gut-brain axis's role in pain modulation.
  • To summarize evidence on microbiota, stress, and pain, including probiotic efficacy.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of studies on gut-brain axis and pain mechanisms.
  • Synthesis of findings on stress, microbiota composition, and pain perception.

Main Results:

  • Gut microbiota dysregulation is implicated in various pain disorders.
  • Stress significantly impacts gut microbiota, influencing pain sensitivity.
  • Probiotics demonstrate promising therapeutic potential in pain management.

Conclusions:

  • The gut-brain axis is a key regulator of pain.
  • Modulating the gut microbiota via probiotics may offer novel pain management strategies.
  • Further research into mechanistic effects is warranted for targeted therapies.
Keywords:
gut-brain axismicrobiotapainprobiotics

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