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Related Experiment Video

Updated: Sep 29, 2025

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments

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Microbiota and Pain: Save Your Gut Feeling.

Chiara Morreale¹, Ilia Bresesti¹, Annalisa Bosi²

¹Department of Woman and Child, ASST-Settelaghi, University of Insubria, 21100 Varese, Italy.

|March 25, 2022

Summary

The gut-brain axis influences pain perception. Probiotics show potential for managing pain by modulating the gut microbiota, offering new therapeutic avenues for pain relief.

Keywords:

gut-brain axis microbiota pain probiotics

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Area of Science:

Neuroscience
Microbiology
Gastroenterology

Background:

The gut-brain axis, a bidirectional communication network, plays a crucial role in health and disease.
Emerging evidence links microbiota dysregulation to pain conditions like visceral hypersensitivity and inflammatory pain.
The gut microbiota's composition is influenced by stress, impacting pain perception.

Purpose of the Study:

To review the mechanisms of pain processing and regulation.
To highlight the gut-brain axis's role in pain modulation.
To summarize evidence on microbiota, stress, and pain, including probiotic efficacy.

Main Methods:

Narrative review of existing literature.
Analysis of studies on gut-brain axis and pain mechanisms.
Synthesis of findings on stress, microbiota composition, and pain perception.

Main Results:

Gut microbiota dysregulation is implicated in various pain disorders.
Stress significantly impacts gut microbiota, influencing pain sensitivity.
Probiotics demonstrate promising therapeutic potential in pain management.

Conclusions:

The gut-brain axis is a key regulator of pain.
Modulating the gut microbiota via probiotics may offer novel pain management strategies.
Further research into mechanistic effects is warranted for targeted therapies.