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Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
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Cardiovascular Inflammaging: Mechanisms and Translational Aspects

Maria Luisa Barcena1,2, Muhammad Aslam3,4,5, Sofya Pozdniakova1,6

  • 1Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.

Cells
|March 25, 2022
PubMed

Insights

Aging accelerates chronic diseases and frailty through cellular damage. This review explores cardiovascular aging, focusing on inflammation (inflammaging) and its molecular mechanisms.

Area of Science:

  • Gerontology
  • Cardiovascular Biology
  • Molecular Medicine

Background:

  • Aging is a primary non-reversible risk factor for chronic diseases like cancer, diabetes, dementia, and cardiovascular diseases (CVD).
  • Aging contributes significantly to multimorbidity, disability, and frailty.
  • Key cellular mechanisms of aging include telomere shortening, inflammation, oxidative stress, mitochondrial dysfunction, cellular senescence, and reduced autophagy.

Purpose of the Study:

  • To review the molecular mechanisms of cardiovascular aging.
  • To explore the translational aspects of cardiovascular aging-related inflammation, termed inflammaging.

Main Methods:

  • Literature review focusing on molecular mechanisms of aging.
  • Analysis of cellular processes contributing to cardiovascular aging.
  • Examination of inflammaging as a central component of cardiovascular aging.

Main Results:

  • Cardiovascular aging involves complex multifactorial cellular processes.
  • Chronic low-grade inflammation, or inflammaging, is a critical aspect of cardiovascular aging.
  • Molecular pathways underlying inflammaging contribute to age-related cardiovascular decline.

Conclusions:

  • Understanding the molecular basis of inflammaging is crucial for addressing age-related cardiovascular diseases.
  • Targeting inflammaging pathways may offer therapeutic strategies for cardiovascular aging.
  • Further research into translational aspects can bridge basic science and clinical applications for cardiovascular health in aging populations.

Keywords:
cardiac inflammagingmicrobiomemitochondrial homeostasisvascular senescence

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