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Related Concept Videos

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A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Extracellular Matrix01:29

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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The Interplay between Cell-Extracellular Matrix Interaction and Mitochondria Dynamics in Cancer.

Bian Yanes1, Elena Rainero1

  • 1School of Biosciences, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

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The extracellular matrix (ECM) and mitochondria interact to drive cancer progression. ECM remodeling influences mitochondrial function, enhancing cancer cell metabolism, invasion, and metastasis.

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • The tumor microenvironment, especially the extracellular matrix (ECM), is crucial for tumor growth and metastasis.
  • Cancer cell metabolism and mitochondrial dynamics are altered during tumorigenesis.
  • The relationship between ECM remodeling and mitochondrial function in cancer is not well understood.

Purpose of the Study:

  • To review the interplay between extracellular matrix remodeling and mitochondrial function in cancer.
  • To highlight how ECM changes influence cancer cell metabolism, invasion, and metastasis.

Main Methods:

  • Literature review of recent research on ECM, mitochondria, and cancer.
  • Synthesis of findings on ECM remodeling's impact on mitochondrial dynamics and cancer progression.

Main Results:

  • ECM remodeling during tumorigenesis affects mitochondrial function.
  • This interaction promotes cancer cell metabolic plasticity.
  • Metabolic changes fuel cancer cell invasion and metastasis.

Conclusions:

  • The ECM-mitochondria axis is a key regulator of cancer progression.
  • Targeting this axis could offer new therapeutic strategies for cancer metastasis.