Related Experiment Video
Updated: Sep 29, 2025
09:04
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
743
Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics
Daniel J García-Domínguez1,2, Lourdes Hontecillas-Prieto1,2, Natalia Palazón-Carrión2
1Clinical Laboratory, Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Seville, Virgen Macarena University Hospital, 41009 Seville, Spain.
Cancers
|March 25, 2022
Summary
Epigenetic alterations in lymphoma impact tumor cells and the immune microenvironment. Understanding these epigenetic changes offers new therapeutic strategies for relapsed or refractory lymphoma.
Area of Science:
- Oncology
- Immunology
- Epigenetics
Background:
- Lymphoma, a cancer of lymphocytes, presents diverse subtypes with poor outcomes in relapsed/refractory cases.
- Epigenetic dysregulation is crucial in cancer development, progression, and treatment resistance.
- While epigenetic changes in lymphoma cells are studied, those affecting the tumor microenvironment's immune cells are less understood.
Purpose of the Study:
- To review epigenetic alterations in both lymphoma cells and tumor-infiltrating immune cells.
- To explore the epigenetic cross-talk between lymphoma and immune cells within the tumor microenvironment.
- To highlight the therapeutic potential of targeting epigenetic mechanisms in lymphoma.
Main Methods:
- Literature review of epigenetic mechanisms in lymphoma.
- Analysis of studies investigating epigenetic aberrations in lymphoma cells.
- Examination of research on epigenetic modifications in immune cells within the lymphoma microenvironment.
Main Results:
- Epigenetic aberrations are implicated in lymphoma initiation, progression, and drug resistance.
- Dysregulated epigenetic mechanisms affect not only lymphoma cells but also immune cells in the tumor microenvironment.
- Emerging epigenetic therapies show promise for lymphoma treatment.
Conclusions:
- Epigenetic alterations play a significant role in lymphoma pathogenesis and progression.
- Further research into the epigenetic interplay between lymphoma and immune cells is essential.
- Targeting epigenetic pathways presents a promising avenue for novel lymphoma therapies.
Related Concept Videos
02:17The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
01:27Tumor Immunotherapy
699
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
699
01:37Epigenetic Regulation
3.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.2K
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
02:38Mitogens and the Cell Cycle
7.0K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.0K