Related Experiment Video
Updated: Sep 29, 2025
09:31
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
9.3K
Mesothelin: An Immunotherapeutic Target beyond Solid Tumors.
Joshua R Faust1, Darcy Hamill1, Edward Anders Kolb1
1Nemours Centers for Childhood Cancer Research & Cancer and Blood Disorders, Nemours Children's Hospital, Wilmington, DE 19803, USA.
Cancers
|March 25, 2022
Summary
Mesothelin, a protein overexpressed in cancers like acute myeloid leukemia (AML), shows promise for targeted therapies. Immunotherapies targeting mesothelin offer a new avenue for treating difficult-to-cure AML.
Area of Science:
- Oncology
- Immunology
- Biochemistry
Background:
- Targeted cancer therapies depend on tumor-specific antigens.
- Mesothelin is a cell surface protein overexpressed in various cancers, including acute myeloid leukemia (AML).
Purpose of the Study:
- To explore the potential of mesothelin as a target for novel cancer therapies, particularly in AML.
Main Methods:
- Review of current research on mesothelin's role in cancer.
- Analysis of various immunotherapeutic modalities targeting mesothelin in AML models.
- In vitro and in vivo studies of mesothelin-targeted treatments.
Main Results:
- Mesothelin is implicated in regulating cell proliferation, growth, and signaling.
- Mesothelin-targeted immunotherapies show potential in preclinical AML models.
Conclusions:
- Mesothelin represents a promising target for developing innovative cancer treatments.
- Targeting mesothelin offers a unique strategy for treating challenging hematological malignancies like AML.
Related Concept Videos
01:27Tumor Immunotherapy
699
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
699
02:17The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
02:38Mitogens and the Cell Cycle
7.0K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.0K
02:57Targeted Cancer Therapies
7.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.9K
01:19Mesenchymal Stem Cells
5.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.1K