Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy

Area of Science:

• Immunology
• Genetics
• Oncology

Background:

• Innate immunity is vital for pathogen defense and cancer surveillance.
• Dysregulation of innate immunity contributes to inflammatory diseases and cancer.
• Genomic integrity of innate immune cells is essential for organism survival.

Purpose of the Study:

• To review the role of base excision repair (BER) in innate immune and cancer cells.
• To explore the impact of BER on innate immune signaling within the tumor microenvironment.
• To discuss how BER modulation affects cancer therapy and immunotherapy.

Main Methods:

• Literature review focusing on DNA damage repair mechanisms.
• Analysis of the interplay between BER, innate immunity, and cancer.
• Examination of BER's role in genomic stability and immune response.

Main Results:

• Oxidative stress in innate immune cells can cause DNA damage, repaired by BER.
• BER mutations impair DNA repair, leading to genomic instability and immune activation.
• BER factor dysregulation in cancer influences immune cell infiltration into tumors.

Conclusions:

• BER is crucial for maintaining genomic integrity in innate immune and cancer cells.
• Aberrant BER impacts DNA damage accumulation, immune signaling, and tumor microenvironment.
• Understanding BER's role is key for developing effective immune-based cancer therapies.