Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonsteroidal anti-inflammatory agents: an update.

P Amadio, D M Cummings

    American Family Physician
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Do GLP-1RAs and SGLT-2is reduce cardiovascular events in women with type 2 diabetes? A systematic review and meta-analysis.

    Diabetes & metabolism·2020
    Same author

    Evaluation of Mother's Stress during Hospitalization Can Influence the Breastfeeding Rate. Experience in Intensive and Non Intensive Departments.

    International journal of environmental research and public health·2020
    Same author

    Comparing once-weekly semaglutide to incretin-based therapies in patients with type 2 diabetes: a systematic review and meta-analysis.

    Diabetes & metabolism·2018
    Same author

    Comparing SGLT-2 inhibitors to DPP-4 inhibitors as an add-on therapy to metformin in patients with type 2 diabetes: A systematic review and meta-analysis.

    Diabetes & metabolism·2018
    Same author

    Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.

    Biochimica et biophysica acta·2016
    Same author

    Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.

    Nature neuroscience·2015

    Nonsteroidal anti-inflammatory drugs (NSAIDs) offer pain relief and reduce inflammation by inhibiting prostaglandin synthesis. Elderly patients require frequent monitoring due to potential gastrointestinal, renal, and hepatic toxicities associated with NSAID use.

    Area of Science:

    • Pharmacology
    • Internal Medicine
    • Geriatrics

    Background:

    • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic and anti-inflammatory properties.
    • Their mechanism of action involves the inhibition of prostaglandin synthesis.
    • NSAIDs exhibit high plasma protein binding and variable half-lives, influencing their pharmacokinetic profiles.

    Purpose of the Study:

    • To highlight the known gastrointestinal adverse effects of NSAIDs.
    • To characterize the recently recognized renal and hepatic toxicities associated with NSAID use.
    • To emphasize the increased risk of NSAID toxicity in elderly patients.

    Main Methods:

    • Review of existing literature on NSAID pharmacology and toxicology.
    • Analysis of clinical data regarding NSAID-related adverse events.

    Related Experiment Videos

  • Focus on pharmacokinetic properties and organ-specific toxicities.

    • Main Results:

    • NSAIDs effectively inhibit prostaglandin synthesis, providing therapeutic benefits.
    • Gastrointestinal reactions are common adverse effects of NSAIDs.
    • Renal and hepatic toxicities of NSAIDs are increasingly recognized, particularly in vulnerable populations.

    Conclusions:

    • Elderly patients are at a higher risk for NSAID-induced toxicities.
    • Frequent medical evaluation is recommended for elderly patients taking NSAIDs.
    • Awareness of renal and hepatic risks is crucial for safe NSAID prescribing.