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Related Experiment Videos

Current therapy, present limitations and future goals for systemic hypertension.

R C Tarazi, F M Fouad-Tarazi

    The American Journal of Cardiology
    |September 30, 1986
    PubMed
    Summary

    Despite advances, hypertension control remains a challenge, with many patients inadequately managed. Newer therapies like calcium channel blockers offer improved metabolic profiles for better cardiovascular outcomes in hypertension treatment.

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    Hypertension hemodynamics.

    The Medical clinics of North America·1997

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Significant progress in hypertension recognition and treatment over two decades.
    • Two-thirds of US hypertensive patients remain inadequately controlled.
    • Antihypertensive therapy's impact on coronary artery disease (CAD) morbidity and mortality is not conclusively demonstrated.

    Purpose of the Study:

    • To address persistent challenges in hypertension control.
    • To evaluate newer antihypertensive therapies potentially overcoming limitations of traditional treatments.
    • To highlight the role of calcium channel blockers in hypertension management.

    Main Methods:

    • Review of antihypertensive therapy, focusing on traditional step-care (diuretics, beta blockers) and newer agents.
    • Assessment of metabolic and hemodynamic profiles of different drug classes.

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  • Examination of clinical outcomes related to coronary artery disease.

    • Main Results:

    • Traditional therapies (diuretics, beta blockers) are associated with unfavorable metabolic effects.
    • These metabolic effects may hinder the demonstration of decreased coronary artery disease.
    • Newer antihypertensive agents, particularly calcium channel blockers, offer favorable metabolic and hemodynamic profiles.
    • Nitrendipine, a long-acting 1,4 dihydropyridine calcium channel blocker, shows promising results.

    Conclusions:

    • Reappraisal of traditional step-care antihypertensive therapy is warranted.
    • Calcium channel blockers are effective, well-tolerated, and metabolically favorable options.
    • Nitrendipine represents a promising new agent for effective hypertension treatment.