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Multiple Sclerosis and Microbiome

Jana Lizrova Preiningerova1, Zuzana Jiraskova Zakostelska2, Adhish Srinivasan1

  • 1Department of Neurology and Centre of Clinical Neuroscience, First Medical Faculty, Charles University and General Medical Hospital in Prague, 12800 Prague, Czech Republic.

Biomolecules
|March 25, 2022
PubMed

Insights

The gut microbiome influences multiple sclerosis (MS) development and progression. Understanding gut-brain axis interactions is key for novel MS therapeutic strategies targeting the microbiome.

Area of Science:

  • Neuroimmunology
  • Microbiome Research
  • Autoimmune Diseases

Background:

  • The gut-brain axis and microbiota composition are implicated in various diseases.
  • Multiple sclerosis (MS) etiology is complex, with potential gut-brain axis involvement.

Purpose of the Study:

  • To explore the relationship between gut microbiota and MS pathophysiology.
  • To review germ-free mouse studies on MS and microbiome modulation.

Main Methods:

  • Literature review focusing on gut microbiota and MS.
  • Analysis of germ-free mouse models in MS research.

Main Results:

  • Gut microbiota composition is linked to MS pathology.
  • Germ-free mouse studies provide insights into MS mechanisms.

Conclusions:

  • Microbiome modulation presents potential therapeutic avenues for MS.
  • Further research is needed on microbiota's role in MS patient response to treatments.
Keywords:
disease-modifying drugsgut-brain axismicrobiomemultiple sclerosis

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