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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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Cross-Talk between p53 and Wnt Signaling in Cancer

Qiyun Xiao1, Johannes Werner2, Nachiyappan Venkatachalam1

  • 1Department of Medicine II, Mannheim University Hospital, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany.

Biomolecules
|March 25, 2022
PubMed

Insights

The p53 and Wnt pathways interact in cancer, influencing tumor growth and resistance to therapy. Understanding these interactions is key to developing new cancer treatments targeting this cross-talk.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • Targeting cancer hallmarks is crucial for antineoplastic treatment.
  • Pathway cross-talk often leads to resistance against targeted therapies.
  • The p53 and Wnt pathways are vital in tumor onset and progression.

Purpose of the Study:

  • To provide a comprehensive overview of molecular interactions between the p53 and Wnt pathways in cancer.
  • To describe the mutational landscape of genes in p53 and Wnt signaling.
  • To discuss the functional consequences and therapeutic targeting of p53-Wnt cross-talk.

Main Methods:

  • Literature review of molecular interactions.
  • Analysis of genetic alterations in p53 and Wnt pathways.
  • Summary of functional consequences and therapeutic strategies.

Main Results:

  • Detailed description of molecular interactions, including feedback loops and reciprocal transactivation.
  • Characterization of mutual exclusive and co-occurring genetic alterations.
  • Identification of functional consequences like invasiveness, metastasis, and drug resistance.

Conclusions:

  • The cross-talk between p53 and Wnt pathways significantly impacts cancer phenotypes.
  • Targeting the p53-Wnt interaction presents potential therapeutic strategies for cancer treatment.
Keywords:
APCWntbeta-catenincancerdrug resistancemetastasisp53

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