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Gastroesophageal Reflux in Children with Asthma

Vasile Valeriu Lupu1, Ingrith Miron1, Elena Tarca2

  • 1Pediatrics Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Children (Basel, Switzerland)
|March 25, 2022
PubMed

Insights

Asthma in children is strongly linked to gastroesophageal reflux (GER), with over 69% of patients showing GER. Treating GER with proton pump inhibitors improved symptoms, suggesting GER management is crucial for pediatric asthma care.

Area of Science:

  • Pediatric Gastroenterology
  • Pulmonology
  • Clinical Research

Background:

  • A potential causal link between asthma and gastroesophageal reflux (GER) is recognized.
  • Gastric reflux aspiration can trigger and sustain bronchospasm, leading to asthma exacerbations.
  • This study investigates the association and treatment outcomes in children with asthma and GER.

Purpose of the Study:

  • To explore the relationship between asthma and GER in children.
  • To evaluate the efficacy of proton pump inhibitors in managing GER in asthmatic children.
  • To assess the impact of GER treatment on asthma control.

Main Methods:

  • 56 children with asthma underwent 24-hour esophageal pH monitoring.
  • The Boix-Ochoa score was utilized to quantify GER.
  • Patients diagnosed with GER received proton pump inhibitors for two months.

Main Results:

  • GER was identified in 69.64% of the pediatric asthma patients.
  • Asthma diagnosis was found to increase the likelihood of GER by 2.86 times.
  • Following a two-month proton pump inhibitor treatment, 17.95% of patients still exhibited elevated GER indicators.

Conclusions:

  • Gastroesophageal reflux is highly prevalent in children with asthma.
  • Screening for and treating GER can significantly aid in the management of pediatric asthma.
  • GER treatment may resolve asthma cases resistant to conventional therapies.

Keywords:
24 h esophageal pH-metryBoix-Ochoa scoreasthmachildrengastroesophageal reflux

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