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Updated: Sep 29, 2025

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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The Composition and Physical Properties of Clots in COVID-19 Pathology

Sierk Dauwerse1, Hugo Ten Cate2,3,4, Henri M H Spronk1,2,3

  • 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.

Diagnostics (Basel, Switzerland)
|March 25, 2022
PubMed

Insights

Rotational ThromboElastoMetry (ROTEM) shows promise in predicting outcomes for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients. This review explores ROTEM

Area of Science:

  • Coagulation and Thrombosis Research
  • Infectious Disease Pathophysiology

Background:

  • Hemostasis dysregulation can cause bleeding or thrombosis.
  • COVID-19 patients exhibit a hypercoagulable state, increasing thrombotic risk.
  • Routine coagulation assays are insufficient for predicting thrombotic events in COVID-19.

Purpose of the Study:

  • To review the utility of ROtational ThromboElastoMetry (ROTEM) in COVID-19 patients.
  • To focus on interpreting ROTEM clot formation curves in relation to COVID-19 coagulopathy.
  • To introduce novel ROTEM parameters for improved patient outcome prediction.

Main Methods:

  • Review of existing literature on ROTEM in COVID-19.
  • Analysis of ROTEM clot formation curve symmetry.
  • Introduction and discussion of new ROTEM parameters.

Main Results:

  • ROTEM is a promising tool for predicting outcomes in hospitalized COVID-19 patients.
  • Specific ROTEM curve characteristics correlate with coagulopathy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
  • New ROTEM parameters may enhance differentiation of COVID-19 patient outcomes.

Conclusions:

  • ROTEM offers valuable insights into COVID-19-associated coagulopathy.
  • ROTEM may improve the prediction of thrombotic events and patient outcomes in COVID-19.
  • Further research into novel ROTEM parameters is warranted.

Keywords:
COVID-19ROTEMhypercoagulability

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