Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aqueous humour outflow improvement after excimer laser trabeculostomy.

The British journal of ophthalmology·2026
Same author

Single-Cell Transcriptomics on <i>PRPF31</i>-Mutated Retinal Organoids Reveal Early Müller Glial Activation and Progressive Photoreceptor Degeneration.

Biomedicines·2026
Same author

Additional Effects of Faricimab in Aflibercept Low-Responders: Retinal Morphology and Function in Eyes with Neovascular Age Related Macular Degeneration Following a Switch Between Two Anti-VEGF Agents.

Clinical ophthalmology (Auckland, N.Z.)·2025
Same author

Randomized controlled bilateral comparison of femtosecond laser-assisted cataract surgery versus conventional phacoemulsification.

BMJ surgery, interventions, & health technologies·2025
Same author

Clinical feasibility of the ESCRS IOL power calculator.

Journal of cataract and refractive surgery·2025
Same author

Exploring organoid and assembloid technologies: a focus on retina and brain.

Expert reviews in molecular medicine·2025

Related Experiment Video

Updated: Sep 29, 2025

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells
06:38

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells

Published on: April 21, 2021

3.1K

Retinal Organoids and Retinal Prostheses: An Overview.

Alessandro Bellapianta1, Ana Cetkovic1, Matthias Bolz1

  • 1Center for Medical Research, Faculty of Medicine, University Clinic for Ophthalmology and Optometry, Johannes Kepler University Linz, 4020 Linz, Austria.

International Journal of Molecular Sciences
|March 25, 2022
PubMed
Summary

This review covers advances in retinal organoids (ROs) derived from induced pluripotent stem cells (iPSCs) and electronic retinal prostheses. These technologies offer new hope for treating vision loss from retinal dystrophies and age-related diseases.

Keywords:
3D modelsblindnessiPSCsorganic semiconductorsphotovoltaic polymersrestore visionretinal dystrophyretinal organoidsretinal prosthesis

More Related Videos

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

3.8K
Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
10:05

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells

Published on: April 12, 2021

6.2K

Related Experiment Videos

Last Updated: Sep 29, 2025

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells
06:38

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells

Published on: April 21, 2021

3.1K
Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

3.8K
Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
10:05

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells

Published on: April 12, 2021

6.2K

Area of Science:

  • Biomedical Engineering
  • Ophthalmology
  • Regenerative Medicine

Background:

  • Millions suffer visual impairment from retinal dystrophies (RDs) and age-related diseases.
  • Induced pluripotent stem cells (iPSCs) and 3D retinal organoids (ROs) offer disease modeling and therapeutic potential.
  • Electronic retinal prostheses using advanced materials are emerging as a treatment strategy.

Purpose of the Study:

  • To review recent advancements in retinal organoid technology.
  • To provide an overview of current retinal prosthesis technologies.
  • To summarize the potential applications of ROs in treating vision loss.

Main Methods:

  • Review of literature on iPSC-derived RO differentiation protocols.
  • Analysis of current inorganic and organic retinal prosthesis technologies.
  • Discussion of RD animal models and their relevance.

Main Results:

  • ROs provide a platform for studying retinal diseases.
  • Retinal prostheses show promise for vision restoration.
  • Combined approaches may offer synergistic therapeutic benefits.

Conclusions:

  • ROs are valuable tools for understanding and potentially treating RDs.
  • Electronic retinal prostheses offer a viable strategy for late-stage vision loss.
  • Further research into both ROs and prostheses is crucial for clinical translation.