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Mesenchymal Stem Cell-Derived Extracellular Vesicles: Pleiotropic Impacts on Breast Cancer Occurrence, Development,
Yiling Guo1,2, Yujia Zhai1,3, Longyuan Wu1,4
1Department of Pathophysiology, Medical College, Nanchang University, 461 Bayi Road, Nanchang 330006, China.
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) play a dual role in breast cancer (BC) progression, influencing tumor development and offering new therapeutic strategies for BC treatment.
Area of Science:
- Oncology
- Cell Biology
- Biotechnology
Background:
- Breast cancer (BC) is a leading cause of female mortality worldwide.
- Mesenchymal stem cells (MSCs) are crucial in the tumor microenvironment (TME) and BC progression.
- Extracellular vesicles (EVs) mediate communication between MSCs and BC cells.
Purpose of the Study:
- To review the multifaceted roles of MSC-derived EVs (MSC-EVs) in breast cancer.
- To explore the therapeutic potential of MSC-EVs in clinical applications for BC.
Main Methods:
- Literature review of studies investigating MSC-EVs in breast cancer.
- Analysis of molecular cargo and functional effects of MSC-EVs.
- Evaluation of MSC-EVs as drug delivery vehicles.
Main Results:
- MSC-EVs deliver diverse molecules (lipids, proteins, nucleic acids) influencing BC.
- MSC-EVs exhibit context-dependent inhibitory and promotive effects on BC.
- MSC-EVs show promise as carriers for targeted drug delivery in BC therapy.
Conclusions:
- MSC-EVs are key mediators in BC progression and TME modulation.
- MSC-EVs represent a promising avenue for novel breast cancer therapeutic strategies.
- Further research into MSC-EVs can establish a basis for clinical translation in BC treatment.
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