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An immunologic study of psoriasis.

A A Fattah, M el Okby, S Ammar

    The American Journal of Dermatopathology
    |August 1, 1986
    PubMed
    Summary
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    Humoral immunity plays a role in psoriasis. Researchers found immunoglobulin and complement deposits in psoriatic skin lesions and elevated IgA and IgG levels in patients, suggesting involvement in disease pathogenesis.

    Area of Science:

    • Immunology
    • Dermatology
    • Pathogenesis of Psoriasis

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • The role of humoral immunity in psoriasis pathogenesis requires further elucidation.

    Purpose of the Study:

    • To investigate the involvement of humoral immune factors in the pathogenesis of psoriasis.
    • To assess immunoglobulin and complement component deposition in psoriatic skin lesions.
    • To evaluate serum levels of immunoglobulins in psoriasis patients.

    Main Methods:

    • Direct immunofluorescence study of skin biopsy specimens from psoriasis lesions and uninvolved skin.
    • Analysis of skin biopsy specimens for immunoglobulin (IgA, IgG, IgM) and complement (Clq, C3) deposits.
    • Measurement of serum IgA, IgG, and IgM levels in patients and normal controls.

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    Main Results:

    • Immunoglobulin and complement deposits were detected in the stratum corneum, Munro's microabscesses, spongiform pustules of Kogoj, stratum malpighii, dermal blood vessels, and inflammatory cells in psoriatic lesions.
    • No significant deposits were found in uninvolved skin of patients or in normal controls.
    • Patients with psoriasis showed significantly increased mean serum levels of IgA and IgG compared to controls.
    • Serum IgM levels were within the normal range in psoriasis patients.

    Conclusions:

    • Humoral immune system abnormalities are present in psoriasis.
    • The observed immunoglobulin and complement deposition in skin lesions suggests a role in psoriasis pathogenesis.
    • Elevated serum IgA and IgG levels further support the involvement of humoral immunity in the disease.