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Updated: Sep 29, 2025

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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Structural Modifications on Chalcone Framework for Developing New Class of Cholinesterase Inhibitors

Ginson George1, Vishal Payyalot Koyiparambath1, Sunitha Sukumaran1

  • 1Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi 682 041, India.

International Journal of Molecular Sciences
|March 25, 2022
PubMed
Summary

Chalcones, versatile compounds with drug-like properties, show promise for Alzheimer's disease (AD) treatment. This review highlights their potential as privileged structures for developing new AD therapies, focusing on cholinesterase inhibition.

Keywords:
acetylcholinesterasebutyrylcholinesterasechalconesstructure activity relationships

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