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Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities
Asad Jamal1, Tian Yuan1, Stefano Galvan1
1Department of Mechanical Engineering, Imperial College London, London SW7 2AZ, UK.
International Journal of Molecular Sciences
|March 25, 2022
Summary
Targeted drug delivery in the brain, like convection-enhanced delivery (CED), faces challenges due to poor understanding of transport mechanisms. This review explores biomechanical and biochemical factors, robotics, and clinical implications for treating brain diseases.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Drug Delivery Systems
Background:
- Targeted drug delivery is crucial for treating aggressive brain diseases like glioblastoma.
- Infusion-based methods such as convection-enhanced delivery (CED) offer localized treatment but are limited by incomplete understanding of transport mechanisms.
- Effective drug delivery to the brain remains a significant challenge in neuro-oncology.
Purpose of the Study:
- To review the biomechanical and biochemical aspects of infusion-based targeted drug delivery in the brain.
- To explore the molecular mechanisms underlying drug transport during infusion.
- To discuss advances and challenges in medical robotics for brain drug delivery.
Main Methods:
- Literature review focusing on biomechanical and biochemical factors in brain drug delivery.
- Analysis of molecular mechanisms of drug transport.
- Examination of current research in medical robotics for targeted drug delivery.
Main Results:
- Identified key biomechanical and biochemical factors influencing drug transport in brain tissue.
- Highlighted the role of molecular mechanisms in localized drug distribution.
- Assessed the integration of medical robotics with infusion techniques for enhanced delivery.
Conclusions:
- A deeper understanding of pressure-driven transport mechanisms is essential for successful clinical application of CED.
- Advances in medical robotics offer promising avenues for improving precision and efficacy in targeted brain drug delivery.
- This review provides a comprehensive overview and new perspectives for future research in brain drug delivery.
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