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Thromboinflammation in Myeloproliferative Neoplasms (MPN)-A Puzzle Still to Be Solved

Vikas Bhuria1,2,3, Conny K Baldauf1,2, Burkhart Schraven1,2,3

  • 1Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.

International Journal of Molecular Sciences
|March 25, 2022
PubMed

Insights

Myeloproliferative neoplasms (MPNs) cause a prothrombotic state and inflammation. This review explores MPN thromboinflammation, neutrophil involvement, and potential therapeutic targets to reduce disease burden.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by excessive myeloid cell proliferation.
  • MPNs are associated with a significant prothrombotic state, leading to high rates of venous and arterial thrombosis.
  • Constitutional symptoms like fatigue and fever are common in MPN patients, linked to chronic inflammation and cytokine dysregulation.

Purpose of the Study:

  • To review the current understanding of thromboinflammation in MPNs.
  • To elucidate the role of neutrophils in the prothrombotic state associated with MPNs.
  • To identify potential molecular mechanisms and therapeutic targets for managing MPN-related thrombosis and inflammation.

Main Methods:

  • Literature review focusing on thromboinflammation in MPNs.
  • Analysis of the role of JAK2-V617F mutation in myeloid cell activation and adhesion.
  • Examination of inflammatory cytokine profiles in MPN patients.

Main Results:

  • The JAK2-V617F mutation activates myeloid cell integrins, promoting adhesion and thrombosis.
  • Neutrophils play a critical role in the prothrombotic state of MPNs.
  • MPN thromboinflammation involves a complex interplay of cytokines and cellular activation.

Conclusions:

  • Understanding MPN thromboinflammation is crucial for patient management.
  • Targeting neutrophil activation and inflammatory pathways may offer novel therapeutic strategies.
  • Further research into molecular mechanisms can lead to effective treatments for reducing MPN disease burden.
Keywords:
MPNinflammatory cytokinesintegrinsneutrophilsthromboinflammation

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