Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.6K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

9.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.2K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

778
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
778
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

709
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
709
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.5K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.5K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

9.1K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycogen drives the sensory activation of POMC neurons.

Nature metabolism·2026
Same author

Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice.

Cell metabolism·2026
Same author

Quality of Life and Experience of Patients with Heart Failure with Preserved Ejection Fraction and Their Caregivers.

Journal of clinical medicine·2025
Same author

Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms.

The Journal of clinical investigation·2025
Same author

Reducing the Burden of Heart Failure in Japan With Dapagliflozin　- A Cost Offset Model (IMPLICATION HF).

Circulation reports·2025
Same author

Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms including sleep.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Sep 29, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.1K

Oncogenic Pathways in Neurodegenerative Diseases.

Luis Varela1, Maria E R Garcia-Rendueles2

  • 1Yale Center for Molecular and Systems Metabolism, Department of Comparative Medicine, School of Medicine, Yale University, 310 Cedar St. BML 330, New Haven, CT 06520, USA.

International Journal of Molecular Sciences
|March 25, 2022
PubMed
Summary

Cancer and neurodegenerative diseases share common molecular signaling pathways. Understanding how these pathways lead to opposite outcomes—cell survival in cancer versus cell death in neurodegeneration—is crucial for developing new treatments.

Keywords:
AlzheimerHuntingtonMAPKMYCNRF2PI3KParkinsonTGFβWNTcancercell cyclehipponeurodegenerative diseasenotchp53

More Related Videos

High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

17.7K
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.5K

Related Experiment Videos

Last Updated: Sep 29, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.1K
High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

17.7K
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.5K

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Oncology

Background:

  • Cancer and neurodegenerative diseases (NDs) are leading causes of mortality, with increasing incidence.
  • Aging global population is expected to double ND prevalence.
  • Both disease types involve dysregulated molecular signaling pathways.

Purpose of the Study:

  • To review common signaling pathways altered in cancer.
  • To analyze these pathways in the context of Alzheimer's, Parkinson's, and Huntington's diseases.
  • To understand the mechanisms behind opposite cellular responses (survival vs. death) to shared molecular triggers.

Main Methods:

  • Literature review of signaling pathways in cancer.
  • Comparative analysis of these pathways in Alzheimer's, Parkinson's, and Huntington's diseases.

Main Results:

  • Identified ten common signaling pathways dysregulated in both cancer and NDs.
  • Highlighted contrasting cellular outcomes: proliferation in cancer, apoptosis in NDs.
  • Detailed the specific roles of these pathways in AD, PD, and HD.

Conclusions:

  • Shared molecular pathways underlie both cancer and NDs.
  • Opposite cellular responses to these pathways offer therapeutic targets.
  • Further research into these mechanisms can improve disease understanding and treatment strategies.