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Updated: Sep 29, 2025
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Author Spotlight: Gut Microbiome-Lung Tissue Communication Through Short-Chain Fatty Acid Analysis
Published on: June 21, 2024
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Short-Chain Fatty Acid Receptors and Cardiovascular Function
Anastasios Lymperopoulos1, Malka S Suster1, Jordana I Borges1
1Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, Fort Lauderdale, FL 33328, USA.
International Journal of Molecular Sciences
|March 25, 2022
Summary
Gut microbes produce short-chain fatty acids (SCFAs) that signal through SCFA receptors (SCFARS) to influence cardiovascular health. Targeting these SCFAR pathways offers potential therapeutic strategies for heart disorders.
Area of Science:
- Microbiology
- Metabolism
- Cardiovascular Physiology
Background:
- The gut microbiome significantly impacts human health, including cardiovascular disorders.
- Free fatty acids (FFAs) are energy substrates, with short-chain FFAs (SCFAs) produced by gut microbiota fermentation of dietary fiber.
- FFAs act as ligands for FFA receptors (FFARs), G protein-coupled receptors (GPCRs) regulating metabolism, immunity, and inflammation.
Purpose of the Study:
- To review the cardiovascular implications of SCFA receptor (SCFAR) signaling pathways.
- To highlight the roles of SCFARs (FFAR2 and FFAR3) in cardiovascular physiology and disease.
- To explore the therapeutic potential of SCFARs for cardiovascular disorders.
Main Methods:
- Literature review focusing on experimental and clinical evidence.
- Analysis of the physiological functions of SCFA signaling pathways.
- Discussion of neurohormonal control and adipose tissue homeostasis related to SCFARs.
Main Results:
- SCFARS (FFAR2 and FFAR3) play crucial roles in cardiovascular physiology.
- SCFAR signaling influences neurohormonal control of circulation.
- SCFAR pathways are implicated in adipose tissue homeostasis.
Conclusions:
- SCFA receptors (FFAR2 and FFAR3) are vital in cardiovascular regulation.
- Understanding SCFA signaling pathways provides insights into cardiovascular health and disease.
- Targeting SCFARs presents a promising therapeutic avenue for cardiovascular disorders.
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