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Related Experiment Videos

Developmental changes in glycoconjugate secretion by ferret tracheas.

M W Leigh, P W Cheng, J L Carson

    The American Review of Respiratory Disease
    |October 1, 1986
    PubMed
    Summary

    Tracheal glycoconjugate secretion is higher in newborn ferrets, with mucin release decreasing rapidly post-birth. Secretory cells show increased synthesis capacity in neonates, with responsiveness to secretagogues developing later.

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    Area of Science:

    • Respiratory physiology
    • Glycoconjugate biochemistry
    • Developmental biology

    Background:

    • The ferret trachea's surface epithelium and submucosal glands undergo significant postnatal development.
    • High molecular weight glycoconjugates, including mucins and glycosaminoglycans, are crucial components of airway secretions.

    Purpose of the Study:

    • To investigate developmental changes in the rates and types of high molecular weight glycoconjugates secreted by ferret tracheas.
    • To analyze the age-related patterns of mucin and glycosaminoglycan release and their response to secretagogues.

    Main Methods:

    • Explanted ferret tracheas were used to measure the release rates of radiolabeled glycoconjugates (3H-glycoconjugates).
    • Bovine testicular hyaluronidase digestion differentiated between mucins and glycosaminoglycans.

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  • The incorporation of 35S-sulfate and 3H-glucosamine was measured to assess mucin sulfation.

    • Main Results:

    • Unstimulated release of total glycoconjugates was 4-fold higher at birth compared to adulthood.
    • Mucin release was 6-fold higher at birth, rapidly decreasing to adult levels by 28 days.
    • Responsiveness to methacholine and trypsin developed at 28 and 54 days of age, respectively.
    • Increased relative incorporation of 35S-sulfate with age indicated developing acidic properties of secretory cells.

    Conclusions:

    • Ferret tracheal secretory cells exhibit heightened synthesis and release of mucins during early postnatal development.
    • The development of responsiveness to secretagogues and increased mucin sulfation occurs later in postnatal life.
    • These developmental changes reflect evolving secretory and synthetic mechanisms in the tracheal epithelium.