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Updated: Sep 29, 2025
Creation of Abdominal Adhesions in Mice
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The Future of Adhesion Prophylaxis Trials in Abdominal Surgery: An Expert Global Consensus
Rudy Leon De Wilde1, Rajesh Devassy2, Richard P G Ten Broek3
1University Hospital for Gynecology, Carl von Ossietzky University, 26121 Oldenburg, Germany.
Abstract:
Postoperative adhesions represent a frequent complication of abdominal surgery. Adhesions can result from infection, ischemia, and foreign body reaction, but commonly develop after any surgical procedure. The morbidity caused by adhesions affects quality of life and, therefore, it is paramount to continue to raise awareness and scientific recognition of the burden of adhesions in healthcare and clinical research. This 2021 Global Expert Consensus Group worked together to produce consented statements to guide future clinical research trials and advise regulatory authorities. It is critical to harmonize the expectations of research, to both develop and bring to market improved anti-adhesion therapies, with the ultimate, shared goal of improved patient outcomes.
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