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Updated: Sep 29, 2025
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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Chronic Heart Failure: Diagnosis and Management beyond LVEF Classification
Filippos Triposkiadis1, Randall C Starling2
1Department of Cardiology, University of Thessaly, Larissa University General Hospital, 41110 Larissa, Greece.
Journal of Clinical Medicine
|March 25, 2022
Insights
Heart failure (HF) classification traditionally relies on left ventricular ejection fraction (LVEF). New research explores alternative phenotyping and management strategies beyond LVEF for improved patient outcomes.
Area of Science:
- Cardiology
- Medical Diagnostics
- Clinical Management
Background:
- Traditional heart failure (HF) classification and management heavily depend on left ventricular ejection fraction (LVEF).
- This approach has limitations in fully capturing the diverse pathophysiology and clinical presentations of HF.
- Exploring alternative phenotyping methods is crucial for refining diagnostic and therapeutic strategies.
Discussion:
- The study critically examines the established LVEF-based paradigm in heart failure.
- It highlights the need to incorporate additional biomarkers and clinical parameters for comprehensive phenotyping.
- Discusses the implications for personalized treatment algorithms in HF management.
Key Insights:
- Left ventricular ejection fraction (LVEF) is a primary but insufficient metric for heart failure (HF) classification.
- Integrating multi-modal data offers a more nuanced understanding of HF subtypes.
- This shift promises more tailored and effective therapeutic interventions.
Outlook:
- Future research should focus on validating novel phenotyping tools and biomarkers.
- Development of integrated diagnostic platforms for HF is anticipated.
- The goal is to move towards precision medicine in heart failure care.
Abstract:
The classification, phenotyping, and management of heart failure (HF) has been based on the left ventricular (LV) ejection fraction (LVEF) [...].
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