Related Experiment Video
Updated: Sep 29, 2025
09:20
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
6.6K
Chronic Heart Failure: Diagnosis and Management beyond LVEF Classification
Filippos Triposkiadis1, Randall C Starling2
1Department of Cardiology, University of Thessaly, Larissa University General Hospital, 41110 Larissa, Greece.
Journal of Clinical Medicine
|March 25, 2022
Summary
Heart failure (HF) classification traditionally relies on left ventricular ejection fraction (LVEF). New research explores alternative phenotyping and management strategies beyond LVEF for improved patient outcomes.
Area of Science:
- Cardiology
- Medical Diagnostics
- Clinical Management
Background:
- Traditional heart failure (HF) classification and management heavily depend on left ventricular ejection fraction (LVEF).
- This approach has limitations in fully capturing the diverse pathophysiology and clinical presentations of HF.
- Exploring alternative phenotyping methods is crucial for refining diagnostic and therapeutic strategies.
Discussion:
- The study critically examines the established LVEF-based paradigm in heart failure.
- It highlights the need to incorporate additional biomarkers and clinical parameters for comprehensive phenotyping.
- Discusses the implications for personalized treatment algorithms in HF management.
Key Insights:
- Left ventricular ejection fraction (LVEF) is a primary but insufficient metric for heart failure (HF) classification.
- Integrating multi-modal data offers a more nuanced understanding of HF subtypes.
- This shift promises more tailored and effective therapeutic interventions.
Outlook:
- Future research should focus on validating novel phenotyping tools and biomarkers.
- Development of integrated diagnostic platforms for HF is anticipated.
- The goal is to move towards precision medicine in heart failure care.
Related Concept Videos
01:30Heart Failure IV: Classification and Diagnostic Evaluation
58
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
58
01:30Heart Failure V: Medical Management
36
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
36
01:30Heart Failure VII: Nursing Interventions
156
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
156
01:22Heart Failure VI: Adjunct Therapies
47
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
47
01:17Pathophysiology of Heart Failure
1.9K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.9K
01:29Cardiomyopathy V: Interprofessional Care
52
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
52