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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Factors Affecting Illness01:18

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

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Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
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Related Experiment Video

Updated: Sep 29, 2025

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

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The Influence of Modifiable Factors on Breast and Prostate Cancer Risk and Disease Progression.

Keely Tan1, Matthew J Naylor1

  • 1Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Frontiers in Physiology
|March 25, 2022
PubMed
Summary

Lifestyle factors like diet and exercise significantly impact breast and prostate cancer risk. Modifying these can prevent many cancer cases by influencing cellular pathways and inflammation.

Keywords:
breast cancerenvironmentalinflammationlifestylemodifiable risk factorsprostate cancerreactive oxygen species

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Area of Science:

  • Oncology
  • Molecular Biology
  • Epidemiology

Background:

  • Breast and prostate cancers are leading global diagnoses, heavily influenced by hormones.
  • While genetic risks are known, lifestyle factors increasingly link to cancer progression.
  • Up to 50% of cancer cases may be preventable through lifestyle and environmental changes.

Purpose of the Study:

  • To review how modifiable lifestyle factors influence breast and prostate cancer.
  • To connect epidemiological findings with biological mechanisms of cancer development.
  • To explore the impact of lifestyle on metabolic, protein, and transcriptional pathways in cancer.

Main Methods:

  • Literature review integrating epidemiological and biological research.
  • Analysis of studies on physical exercise, diet, and weight management.
  • Examination of effects on inflammation, transcriptional activity, and signaling pathways.

Main Results:

  • Lifestyle factors demonstrably alter cancer cell physiology.
  • Modifiable factors influence key metabolic, protein, and transcriptional pathways.
  • Evidence links lifestyle to breast and prostate cancer risk and patient prognosis.

Conclusions:

  • Understanding lifestyle's molecular impact is crucial for cancer prevention.
  • Integrating lifestyle interventions with biological insights can improve outcomes.
  • Modifiable lifestyle factors represent a significant target for reducing cancer burden.