Related Experiment Video

Updated: Sep 29, 2025

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

11.8K

Transcatheter aortic valve replacement in patients with aortic stenosis and cardiac amyloidosis

Tasveer Khawaja1, Rahul Jaswaney1, Shilpkumar Arora2

  • 1Department of Internal Medicine, Case Western Reserve University, University Hospitals, Cleveland, OH, United States.

International Journal of Cardiology. Heart & Vasculature
|March 25, 2022
PubMed

Insights

Transcatheter aortic valve replacement (TAVR) in patients with cardiac amyloidosis (CA) and aortic stenosis (AS) was associated with improved outcomes. TAVR reduced heart failure readmissions and the composite of mortality and readmissions in this patient group.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Amyloidosis Research

Background:

  • The co-occurrence of aortic stenosis (AS) and cardiac amyloidosis (CA) is increasingly recognized.
  • The effectiveness of transcatheter aortic valve replacement (TAVR) in patients with CA is not well-established.

Purpose of the Study:

  • To evaluate the role and outcomes of TAVR in patients with co-existing CA and AS.
  • To assess the impact of TAVR on heart failure readmissions and all-cause mortality in this population.

Main Methods:

  • Utilized the National Readmission Dataset (2016-2018) with ICD-10 codes to identify patients with CA and AS.
  • Employed Kaplan-Meier curves and multivariate Cox-proportional hazard regression for time-to-event analysis up to 1-year follow-up.
  • Primary outcome was a composite of heart failure readmissions and all-cause mortality.

Main Results:

  • Of 1,127 CA patients, 8.2% underwent TAVR. TAVR patients were younger and more frequently had coronary artery disease.
  • TAVR was associated with a significantly improved primary outcome (8.9% vs 24.4%, HR:0.32, p=0.007).
  • TAVR significantly reduced heart failure readmissions (3.8% vs 19.4%, HR:0.22, p=0.008); all-cause mortality was numerically lower but not statistically significant.

Conclusions:

  • TAVR is performed in younger CA patients, often at large, teaching hospitals.
  • TAVR is associated with a reduced composite outcome of heart failure readmissions and all-cause mortality in patients with cardiac amyloidosis and aortic stenosis.
Abstract

Keywords:
Aortic stenosisCardiac amyloidosisHeart failureTAVR

More Related Videos

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.5K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.0K

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
57
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
32
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
52
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
54