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Updated: Sep 29, 2025

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Site-Specific Binding of Anti-Cancer Drugs to Human Serum Albumin
Mrinalini Bhosale1, Ishtiaq Jeelani2,3, Allah Nawaz3
1Department of Chemistry, Abeda Inamdar Senior College of Arts, Science and Commerce, Savitribai Phule Pune University, Pune 411001, India.
Abstract:
The interaction of drugs with proteins plays a very important role in the distribution of the drug. Human serum albumin (HSA) is the most abundant protein in the human body, showing great binding characteristics, and has gained a lot of importance pharmaceutically. It plays an essential role in the pharmacokinetics of a number of drugs; hence, several reports are available on the interaction of drugs with HSA. It can bind to cancer drugs; thus, it is crucial to look at the binding characteristics of these drugs with HSA. Herein, we summarize the binding properties of some anti-cancer drugs by specifically looking into the binding site with HSA. The number of drugs binding at the Sudlow's site I situated in subdomain II A is more than the drugs binding at Sudlow's site II.
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