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Functionalized Nanostructured Bioactive Carriers: Nanoliposomes, Quantum Dots, Tocosome, and Theranostic Approach
Mehrnoush Mehrarya1, Behnaz Gharehchelou2, Zeinab Kabarkouhi3
1Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
Current Drug Delivery
|March 25, 2022
Summary
Lipid nanocarriers offer advanced drug delivery, improving therapeutic outcomes and reducing side effects. Novel formulations combining nanocarriers with quantum dots, polymers, and nanoparticles show promise for theranostic applications.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Lipid nanocarriers are versatile platforms for encapsulating and delivering bioactive compounds.
- They offer advantages over conventional therapies, including targeted delivery and improved pharmacokinetics.
- These benefits contribute to mitigating the adverse effects of traditional treatments.
Purpose of the Study:
- To review the theranostic applications of novel lipid nanocarrier formulations.
- To explore combinations of lipid nanocarriers with quantum dots, polymers (e.g., chitosan), and metallic nanoparticles.
- To discuss tocosomes as a recent innovation in drug delivery.
Main Methods:
- Review of existing literature on lipid nanocarriers and their theranostic applications.
- Analysis of formulations incorporating quantum dots, chitosan, and gold nanoparticles.
- Examination of tocosomes and their unique drug delivery characteristics.
Main Results:
- Novel lipid nanocarrier formulations exhibit enhanced controlled release and drug loading capabilities.
- These advanced formulations demonstrate a reduced burst release rate.
- Combinations with quantum dots, polymers, and nanoparticles improve drug delivery efficiency.
Conclusions:
- Lipid-based nanocarrier systems and tocosomes are ideal candidates for theranostic medicine.
- Enhanced target-specific accumulation and biodistribution are crucial for effective theranostics.
- These systems, when combined with quantum dots, biocompatible polymers, and metallic nanoparticles, offer safe and efficient drug delivery solutions.
