Related Experiment Video
Updated: Sep 29, 2025
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
Analysis of Thyroid Gland Problems with Shear Wave Elastography in Children with Celiac Disease
Meryem Keceli Basaran1, Okan Gurkan2
1Department of Pediatrics, Division of Pediatric Gastroenterology, Gaziosmanpasa Training and Research Hospital, İstanbul, Turkey.
Insights
Thyroid shear wave elastography (SWE) and ultrasonography (US) effectively diagnose thyroid disease in children with celiac disease (CD). SWE findings correlate with lab results, aiding in diagnosis and monitoring of autoimmune thyroid disease in this population.
Area of Science:
- Pediatric Endocrinology
- Gastroenterology
- Radiology
Background:
- Children with celiac disease (CD) have a high incidence of autoimmune thyroiditis.
- Many euthyroid patients with CD require effective diagnostic tools for thyroid conditions.
- Thyroid imaging, including ultrasonography (US) and shear wave elastography (SWE), is increasingly important for diagnosis and monitoring.
Purpose of the Study:
- To evaluate the diagnostic efficacy of thyroid US and SWE in children with CD.
- To compare thyroid imaging findings between children with and without CD.
- To assess the correlation between imaging findings and laboratory markers of thyroid function and autoimmunity.
Main Methods:
- A cross-sectional controlled study involving 106 children with CD and 103 controls.
- Thyroid US and SWE measurements were performed using an Aplio 500 ultrasound device.
- Serum thyroid function tests and autoimmune antibodies were analyzed concurrently.
Main Results:
- Children with CD exhibited significantly higher thyroid volume and elasticity (kPa, m/s) compared to controls (p < 0.001).
- Positive, moderate correlations were observed between thyroid US/SWE parameters and anti-thyroid peroxidase antibody and TSH levels (r = 0.612-0.636, p < 0.001).
- SWE findings aligned with laboratory results, demonstrating sensitivity and utility.
Conclusions:
- Thyroid shear wave elastography (SWE) is a sensitive and useful method for diagnosing and monitoring autoimmune thyroid disease in children with celiac disease.
- SWE findings complement laboratory tests, providing valuable diagnostic information.
- Thyroid imaging plays a crucial role in the comprehensive management of pediatric celiac disease patients.
Background:
The rate of autoimmune thyroiditis in children with celiac disease (CD) is high relative to the normal population. Since the majority of these patients are also euthyroid, thyroid imaging methods are gaining significance in diagnosis and follow-up. This study examines the effectiveness of thyroid ultrasonography (US) and thyroid shear wave elastography (SWE) in diagnosing thyroid disease in children with CD.
Materials And Methods:
This cross-sectional controlled study analyzed thyroid US, SWE, serum thyroid function tests, and thyroid autoimmune antibodies of 106 CD patients and 103 control patients without CD. An Aplio 500 ultrasound device with a linear array transducer and elastography software was used for thyroid US and SWE measurement of all patients.
Results:
Right lobe thyroid volume, left lobe thyroid volume, total thyroid volume, thyroid mean elasticity (m/s), right lobe elasticity (kPa), left lobe elasticity (kPa), and mean thyroid elasticity (kPa) levels of the CD group were higher than those of the control group (p < 0.001). The relationships between thyroid US and thyroid mean elasticity (m/s), thyroid mean elasticity (kPa), anti-thyroid peroxidase antibody, and thyroid-stimulating hormone were positive and moderate, respectively (r = 0.612, 0.612, 0.636, and 0.565, respectively; p < 0.001).
Conclusion:
In this study, SWE findings were compatible with laboratory findings, as they constituted a sensitive and useful method in the diagnosis and follow-up of autoimmune thyroid disease in children with CD.
More Related Videos
05:56Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
07:13Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
Published on: April 20, 2021
Related Concept Videos
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
01:23The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...