Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Carbohydrate Metabolism01:36

Carbohydrate Metabolism

12.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
12.1K
Bone Disorders01:29

Bone Disorders

4.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

72
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
72
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.4K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.4K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
What is the Skeletal System?01:02

What is the Skeletal System?

54.0K
Overview
54.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Solitary fibrous tumor of the oral cavity: a systematic review of the literature and a new clinicopathologic case report.

Frontiers in oral health·2026
Same author

A Retrospective Analysis of Seven Bacterial Sexually Transmitted Diseases in the City of Bari: Observations and Future Perspectives.

Endocrine, metabolic & immune disorders drug targets·2026
Same author

Retrospective Descriptive Case Series on the Use of AMCOP<sup>®</sup> Elastodontic Appliance in Growing Patients with Class III Malocclusion.

Bioengineering (Basel, Switzerland)·2026
Same author

Platelet Concentrates in Alveolar and Periodontal Bone Regeneration: Adjunctive Benefits and Clinical Comparability with Conventional Approaches: A Systematic Review.

Journal of clinical medicine·2026
Same author

The role of human papillomavirus in oral squamous cell and verrucous carcinomas: a systematic review with case series.

Oncology reviews·2026
Same author

Upper Blepharoplasty in Dermatochalasis: A Retrospective Study of Our Cases.

Journal of maxillofacial and oral surgery·2026

Related Experiment Video

Updated: Sep 29, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

400

Searching for a Link between Bone Decay and Diabetes Type 2.

Ciro G Isacco1,2,3,4,5,6, Kieu C D Nguyen6, Van H Pham2

  • 1Department of Interdisciplinary Medicine (D.I.M.), Bari University of Medicine Aldo Moro, Bari City, Italy.

Endocrine, Metabolic & Immune Disorders Drug Targets
|March 25, 2022
PubMed
Summary

Type 2 diabetes may harm bone health by hindering mesenchymal stem cells from becoming bone-building cells. This molecular link impacts bone integrity in metabolic diseases.

Keywords:
Diabetes type 1-2ageingbone decaybone marrow (BM)central nervous system (CNS)enteric nervous system (ENS)mesenchymal stem cells (MSCs)osteoblastsregenerative medicine

More Related Videos

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

952
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.7K

Related Experiment Videos

Last Updated: Sep 29, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

400
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

952
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.7K

Area of Science:

  • Biomedical Science
  • Metabolic Diseases
  • Bone Biology

Background:

  • Metabolic diseases, including type 2 diabetes, are increasingly prevalent globally.
  • Bone degenerative patterns are a significant health concern, impacting mobility and quality of life.
  • The intricate relationship between metabolic health and skeletal integrity requires further elucidation.

Purpose of the Study:

  • To explore the potential molecular mechanisms linking type 2 diabetes to bone degeneration.
  • To investigate the role of mesenchymal stem cells (MSCs) in this process.
  • To understand how metabolic dysfunction may inhibit osteoblast and osteocyte differentiation.

Main Methods:

  • This commentary synthesizes existing research on molecular pathways.
  • It focuses on the inhibition of mesenchymal stem cell differentiation.
  • The review examines the transition of MSCs into osteoblasts and osteocytes.

Main Results:

  • A potential molecular mechanism is described, linking metabolic diseases to bone issues.
  • Mesenchymal stem cells' differentiation into osteoblasts and osteocytes may be inhibited.
  • This inhibition could underlie the degenerative bone patterns observed in type 2 diabetes.

Conclusions:

  • Metabolic diseases like type 2 diabetes may negatively impact bone health.
  • Inhibition of MSC differentiation is a plausible molecular link.
  • Further research is warranted to confirm and target these pathways for therapeutic interventions.