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Functions and underlying mechanisms of miR-650 in human cancers

Yuanshuai Su1, Qiuxian Zheng1, Lingxiao Zhu1

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang University, Hangzhou, 310003, China.

Cancer Cell International
|March 25, 2022
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and impact cancer. This review details miR-650

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression posttranscriptionally.
  • Dysregulation of miRNAs is implicated in cancer initiation and progression.
  • miRNAs show promise as diagnostic and therapeutic cancer tools.

Purpose of the Study:

  • To review the mechanisms of miR-650 expression alteration in cancer.
  • To explore the relationship between miR-650 and cancer development.
  • To highlight the clinical potential of miR-650 in cancer diagnosis and therapy.

Main Methods:

  • Literature review of existing studies on miR-650 and cancer.
  • Analysis of molecular mechanisms underlying miR-650 dysregulation.
  • Examination of miR-650's role in cancer signaling pathways, including the Wnt/AXIN1 axis.

Main Results:

  • miR-650 plays critical roles in various cancers, notably hepatocellular carcinoma.
  • Altered miR-650 expression is linked to cancer progression.
  • miR-650 is involved in key cancer-related signaling pathways.

Conclusions:

  • Comprehensive understanding of miR-650's expression patterns and mechanisms in cancer is needed.
  • miR-650 represents a promising biomarker for cancer diagnosis.
  • Targeting miR-650 could offer novel therapeutic strategies for cancer treatment.
Keywords:
Biological rolesCancerExpressionMiR-650Oncogenesis

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