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Updated: Sep 29, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

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Hirschsprung disease and Paediatric Intestinal Pseudo-obstruction

Atchariya Chanpong1, Osvaldo Borrelli2, Nikhil Thapar3

  • 1Neurogastroenterology & Motility Unit, Gastroenterology Department, Great Ormond Street Hospital for Children, London, WC1N 3JH, United Kingdom; Division of Gastroenterology and Hepatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand; Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, United Kingdom.

Best Practice & Research. Clinical Gastroenterology
|March 25, 2022
PubMed
Summary

Hirschsprung disease (HSCR) and Paediatric Intestinal Pseudo-obstruction (PIPO) are severe GI motility disorders. Diagnosis relies on histopathology, but advances in manometry and genetics offer new diagnostic tools, while surgery remains key for treatment.

Keywords:
CongenitalConstipationDysmotilityGastrointestinal motilityIntestinal pseudo-obstructionPaediatric

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