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Tissue Engineering of the Intestine in a Murine Model
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Regenerative medicine for childhood gastrointestinal diseases

Brendan C Jones1, Soichi Shibuya2, Natalie Durkin1

  • 1Stem Cell and Regenerative Medicine Section, Developmental Biology and Cancer Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom; Specialist Neonatal and Paediatric Surgery Unit, Great Ormond Street Hospital, London, United Kingdom.

Best Practice & Research. Clinical Gastroenterology
|March 25, 2022
PubMed

Insights

Regenerative medicine offers new hope for children with gastrointestinal diseases causing organ failure. Tissue engineering is advancing rapidly, bringing engineered esophageal and intestinal therapies closer to clinical trials.

Area of Science:

  • Regenerative medicine
  • Bioengineering
  • Gastrointestinal disease research

Background:

  • Paediatric gastrointestinal diseases can lead to severe, life-shortening organ failure.
  • Current treatments for these conditions are often inadequate and lack curative potential.
  • Regenerative medicine seeks to develop cell and tissue-based therapies for organ failure.

Purpose of the Study:

  • To review the requirements for developing bioengineered gastrointestinal therapies.
  • To explore potential sources for cellular and non-cellular components in tissue engineering.
  • To summarize the progress in clinical translation of oesophageal and intestinal tissue engineering.

Main Methods:

  • Review of current literature on regenerative medicine and tissue engineering.
  • Analysis of stem cell biology, materials science, and bioengineering advancements.
  • Assessment of progress towards clinical application of engineered gastrointestinal tissues.

Main Results:

  • Significant advancements in stem cell biology, materials science, and bioengineering.
  • Engineered gastrointestinal cell and tissue therapies are nearing clinical trial stages.
  • Identification of key requirements and component sources for successful tissue engineering.

Conclusions:

  • Tissue-engineered gastrointestinal therapies hold promise for treating paediatric organ failure.
  • Inter-disciplinary collaboration is crucial for advancing these therapies to the clinic.
  • Further research and development are paving the way for clinical translation.

Keywords:
BioengineeringClinical translationCongenital disordersRegenerative medicineTissue engineering

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