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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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The gut-liver axis: host microbiota interactions shape hepatocarcinogenesis

Maruhen A D Silveira1, Steve Bilodeau2, Tim F Greten3

  • 1Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA; Centre de Recherche du CHU de Québec - Université Laval, Axe Oncologie, Québec, QC G1V 4G2, Canada; Centre de Recherche sur le Cancer de l'Université Laval, Québec, QC G1R 3S3, Canada.

Trends in Cancer
|March 25, 2022
PubMed
Summary

Tumors rely on oncogenic transcriptional programs influenced by the tumor microenvironment (TME). Gut microbiota interactions with the TME, particularly in the liver, can disrupt the gut-liver axis, potentially leading to cancer.

Keywords:
dysbiosisgut–liver axisliver cancermicrobiotatumor microenvironment

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