Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.8K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovering Novel intracranial EEG Biomarkers of Seizure Generating Tissue through Time-Frequency Analysis.

medRxiv : the preprint server for health sciences·2026
Same author

Positron Emission Tomography (PET) in Phenylketonuria: A Systematic Review of Brain Metabolism Beyond Phenylalanine.

American journal of medical genetics. Part A·2026
Same author

Internal and external validation of comprehensive high-frequency activity biomarkers for epilepsy surgery.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Cognitive impairment patterns and associated clinical and imaging characteristics in young patients with Sturge-Weber syndrome.

Brain & development·2026
Same author

Active contact proximity to the hyperdirect pathway is associated with bradykinesia response after STN DBS.

Clinical neurology and neurosurgery·2026
Same author

Developmental profile of physiological high-frequency oscillations in the human brain.

NeuroImage·2026

Related Experiment Video

Updated: Sep 29, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K

Temporally and functionally distinct large-scale brain network dynamics supporting task switching.

Takumi Mitsuhashi1, Masaki Sonoda2, Ethan Firestone3

  • 1Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien St, Detroit, MI 48201, USA; Department of Neurosurgery, Juntendo University, Tokyo 113-8421, Japan.

Neuroimage
|March 25, 2022
PubMed
Summary

Brain network dynamics reveal distinct pathways for task switching. High-gamma activity in the visual-precuneus pathway aids attentional shifts, while visual-dorsolateral prefrontal activity reflects response costs.

Keywords:
Cognitive controlEbb and FlowElectrocorticographyEpilepsy surgeryResponsesSynchronization

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.2K

Related Experiment Videos

Last Updated: Sep 29, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.2K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Systems Neuroscience

Background:

  • Human cognition involves rapid switching between competing responses.
  • Understanding the brain's network dynamics during task switching is crucial for cognitive flexibility.
  • Previous research has not fully elucidated the spatiotemporal characteristics of these dynamics.

Purpose of the Study:

  • To determine the spatiotemporal characteristics of brain network dynamics during task switching.
  • To investigate the functional significance of these rapid, large-scale brain network dynamics.
  • To explore the neural basis of cognitive flexibility.

Main Methods:

  • Intracranial electroencephalography (iEEG) recorded brain activity in epilepsy patients during a cognitive flexibility game.
  • Diffusion-weighted imaging (DWI) tractography mapped white matter connections between activated brain regions.
  • Analysis focused on high-gamma augmentation during task switch versus repeat trials, and its modulation by practice.

Main Results:

  • Task switching increased response times, while practice reduced them.
  • High-gamma augmentation was observed in specific brain regions (calcarine cortex, precuneus, entorhinal cortex, middle-frontal gyri) following task cues.
  • DWI confirmed direct white matter connections between some activated regions, and precuneus high-gamma predicted response accuracy.

Conclusions:

  • Two distinct network dynamics support task switching: a visual-precuneus pathway for attentional shifts and a visual-dorsolateral prefrontal pathway for response execution costs.
  • High-gamma augmentation in the visual-precuneus pathway facilitates updating task rules.
  • High-gamma activity in the visual-dorsolateral prefrontal pathway decreases with practice, reflecting reduced stimulus-response translation costs.