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Evaluation of 41 single nucleotide polymorphisms in canine diffuse large B-cell lymphomas using MassARRAY.

Sirintra Sirivisoot1, Tanit Kasantikul2, Somporn Techangamsuwan1

  • 1Center of Excellence for Companion Animal Cancer, Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.

Scientific Reports
|March 25, 2022
PubMed
Summary
This summary is machine-generated.

This study investigated genetic variants in canine diffuse large B-cell lymphoma (DLBCL). Specific single nucleotide polymorphisms (SNPs) were linked to prognosis and potential targeted therapies for canine lymphoma.

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Area of Science:

  • Veterinary Oncology
  • Canine Genetics
  • Lymphoma Research

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is the most common canine lymphoma.
  • Identifying genetic markers can improve diagnosis and treatment strategies for canine DLBCL.

Purpose of the Study:

  • To investigate 41 genetic variants in canine DLBCL using the Agena MassARRAY platform.
  • To correlate specific single nucleotide polymorphisms (SNPs) with prognosis and treatment response in dogs with DLBCL.

Main Methods:

  • Analysis of lymph node biopsies from 60 dogs with B-cell lymphoma.
  • Utilized the Agena MassARRAY platform to screen for 41 pre-selected genetic variants.
  • Examined associations between SNPs, dog breed, and clinical outcomes, including overall survival time (OST).

Main Results:

  • All dogs exhibited SNPs in HYAL4 and SATB1 genes.
  • SEL1L and c-Kit SNPs were less common, with breed-specific exceptions.
  • Purebred dogs showed a higher likelihood of specific FLT3 and TRAF3 SNPs.
  • c-Kit T425 variant correlated with poorer prognosis and shorter OST in DLBCL dogs.
  • Multiple SEL1L variants were associated with decreased median OST in dogs treated with COP chemotherapy.

Conclusions:

  • The identified SNP panel offers valuable prognostic information for canine DLBCL.
  • These genetic findings can guide the development of targeted therapy strategies for individual dogs.
  • Further research into these variants may lead to improved treatment plans and outcomes for canine lymphoma patients.