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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Non-coding RNAs as emerging regulators and biomarkers in colorectal cancer

Chandra Kishore1, Devarajan Karunagaran2

  • 1Life Science Building, Az Rakbe Sidhi Tajpur, Madhepur, Madhubani, Patna, 847408, India.

Molecular and Cellular Biochemistry
|March 25, 2022
PubMed

Insights

Colorectal cancer (CRC) is a major global health issue. This review explores noncoding RNAs as potential biomarkers and therapeutic targets for improved CRC diagnosis and treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) ranks as the third most common cancer globally and the second leading cause of cancer-related mortality.
  • In 2020, CRC accounted for over 1.9 million new cases and more than 935,000 deaths worldwide.
  • Noncoding RNAs have gained significant attention over the past two decades for their roles in various diseases, including cancer.

Purpose of the Study:

  • To review the emerging roles of diverse noncoding RNAs in colorectal cancer.
  • To discuss the potential of noncoding RNAs as prognostic and diagnostic biomarkers for CRC.
  • To explore noncoding RNAs as therapeutic targets for colorectal cancer management.

Main Methods:

  • Literature review of preclinical and clinical studies on noncoding RNAs in CRC.
  • Analysis of the functions of various noncoding RNA types (miRNAs, tsRNAs, piRNAs, lncRNAs, pseudogenes, circRNAs) in CRC pathogenesis.
  • Synthesis of current research on the diagnostic, prognostic, and therapeutic implications of noncoding RNAs in CRC.

Main Results:

  • Noncoding RNAs, including microRNAs (miRNAs), small interfering RNAs (tsRNAs), PIWI-interacting RNAs (piRNAs), long noncoding RNAs (lncRNAs), pseudogenes, and circular RNAs (circRNAs), are implicated in CRC.
  • These noncoding RNAs show promise as sensitive biomarkers for early detection and prognosis of colorectal cancer.
  • Several noncoding RNAs have demonstrated potential as therapeutic targets for novel CRC treatments.

Conclusions:

  • Noncoding RNAs represent a rapidly evolving area in colorectal cancer research.
  • Understanding the multifaceted roles of noncoding RNAs is crucial for advancing CRC management and developing targeted therapies.
  • Further research into noncoding RNAs holds significant promise for improving patient outcomes in colorectal cancer.
Keywords:
BiomarkerColorectal cancerNon-coding RNAsPseudogenescircRNAslncRNAsmiRNAspiRNAstsRNAs

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