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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.9K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.9K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

57
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

95
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
95
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

82
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
82
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

156
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
156
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

67
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
67

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Related Experiment Video

Updated: Sep 29, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

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Development of Advanced Heart Failure: A Population-Based Study.

Anna V Subramaniam1, Susan A Weston2, Jill M Killian2

  • 1Department of Medicine (A.V.S.), Mayo Clinic, Rochester, MN.

Circulation. Heart Failure
|March 25, 2022
PubMed
Summary
This summary is machine-generated.

Advanced heart failure (HF) affects over 11% of patients within six years of diagnosis. Developing advanced HF significantly increases hospitalization and mortality risks, highlighting the need for early intervention.

Keywords:
cardiologyepidemiologyheart failurehospitalizationmortality

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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Last Updated: Sep 29, 2025

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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Area of Science:

  • Cardiology
  • Clinical Research
  • Epidemiology

Background:

  • Advanced heart failure (HF) presents severe symptoms despite optimized medical therapy.
  • Understanding the progression and risk factors for advanced HF is crucial for patient management.
  • This study investigates the incidence, predictors, and outcomes of advanced HF in a population-based cohort.

Purpose of the Study:

  • To examine the risk of developing advanced HF in patients with newly diagnosed HF.
  • To identify key risk factors associated with the progression to advanced HF.
  • To evaluate the impact of advanced HF on patient hospitalization and mortality rates.

Main Methods:

  • A population-based, retrospective cohort study was conducted on residents of Olmsted County, Minnesota, diagnosed with HF between 2007 and 2017.
  • Cause-specific Cox proportional hazard regression models were used to identify risk factors for advanced HF.
  • Andersen-Gill and Cox models assessed the association between advanced HF and risks of hospitalization and mortality.

Main Results:

  • The cumulative incidence of advanced HF was 11.5% at 6 years post-diagnosis.
  • Demographics, comorbidities, and echocardiographic features were independently linked to advanced HF development.
  • Advanced HF significantly increased risks for all-cause hospitalization (aHR, 3.0), HF hospitalization (HR, 10.2), all-cause mortality (aHR, 5.0), and cardiovascular mortality (HR, 7.8).

Conclusions:

  • Progression to advanced heart failure is a common outcome for patients with incident HF.
  • The development of advanced HF is associated with substantially increased morbidity and mortality.
  • Identifying patients at risk for advanced HF is critical for improving outcomes.